| Autor: |
Yibei Zhu, Yunyun Xu, Jianquan Hou, Gehua Yu, Guangbo Zhang, Xueguang Zhang, Xin Gao, Haitao Huang, Cuiping Liu |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
OncoImmunology. 4:e977164 |
| ISSN: |
2162-402X |
| DOI: |
10.4161/2162402x.2014.977164 |
| Popis: |
Myeloid-derived suppressor cells (MDSC) potently inhibit antitumor immune responses, and thereby promoti tumor progression and metastasis. However, the nature of human tumor-infiltrating MDSC remains poorly characterized. Here, we find B7-H3 is exclusively expressed on a subset of intratumoral CD14+HLA-DR−/low MDSC but absent from adjacent normal lung tissues of patients with non-small cell lung carcinoma (NSCLC). Cytokine analysis revealed that B7-H3+CD14+HLA-DR−/low MDSC (B7-H3+MDSC) produced higher levels of IL-10 and TNFα but lower levels of IL-1β and IL-6 when compared with B7-H3−CD14+HLA-DR−/low myeloid-derived suppressor cells (B7-H3−MDSC). In a murine lung cancer model, B7-H3+MDSCs were found only in the tumor microenvironment and their frequencies increased during tumor progression. Clinical data analysis indicated that a higher frequency of B7-H3+MDSCs was associated with reduced recurrence-free survival in patients with NSCLC. Taken together, we identify a novel subset of MDSCs within the tumor microenvironment that fosters tumor progression. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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