Association of plasma Aβ40/Aβ42 ratio and brain Aβ accumulation: testing a whole-brain PLS-VIP approach in individuals at risk of Alzheimer's disease
Autor: | Lemercier, Pablo, Vergallo, Andrea, Hampel, Harald, group, INSIGHT-preAD study, Initiative, the Alzheimer Precision Medicine, Lista, Simone, Zetterberg, Henrik, Blennow, Kaj, Potier, Marie-Claude, Habert, Marie-Odile, Lejeune, François-Xavier, Dubois, Bruno, Teipel, Stefan |
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Přispěvatelé: | Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 AMP), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University of Gothenburg (GU), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], University of Rostock, Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 APM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Gestionnaire, HAL Sorbonne Université 5, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
Aging Subjective memory Disease Preclinical Alzheimer's disease 0302 clinical medicine blood [Amyloid beta-Peptides] Cognitive impairment Default mode network 0303 health sciences blood [Biomarkers] Subjective memory complaints General Neuroscience diagnosis [Alzheimer Disease] Brain 3. Good health blood [Peptide Fragments] whole-brain Female [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] metabolism [Alzheimer Disease] metabolism [Biomarkers] Risk metabolism [Amyloid beta-Peptides] Partial least square 03 medical and health sciences blood [Alzheimer Disease] Salience (neuroscience) Alzheimer Disease Partial least square whole-brain medicine Dementia Humans [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ddc:610 Plasma amyloid β Association (psychology) diagnostic imaging [Brain] 030304 developmental biology Aged Amyloid beta-Peptides business.industry medicine.disease Peptide Fragments Increased risk metabolism [Brain] Positron-Emission Tomography Neurology (clinical) Geriatrics and Gerontology business Neuroscience 030217 neurology & neurosurgery Biomarkers Developmental Biology |
Zdroj: | Neurobiology of Aging Neurobiology of Aging, Elsevier, 2021, 107, pp.57-69. ⟨10.1016/j.neurobiolaging.2021.07.005⟩ Neurobiology of aging 107, 57-69 (2021). doi:10.1016/j.neurobiolaging.2021.07.005 Neurobiology of Aging, 2021, 107, pp.57-69. ⟨10.1016/j.neurobiolaging.2021.07.005⟩ |
ISSN: | 0197-4580 |
Popis: | International audience; Molecular and brain regional/network-wise pathophysiological changes at preclinical stages of Alzheimer's disease (AD) have primarily been found through knowledge-based studies conducted in late-stage mild cognitive impairment/dementia populations. However, such an approach may compromise the objective of identifying the earliest spatial-temporal pathophysiological processes. We investigated 261 individuals with subjective memory complaints, a condition at increased risk of AD, to test a whole-brain, non-a-priori method based on partial least squares in unraveling the association between plasma Aβ42/Aβ40 ratio and an extensive set of brain regions characterized through molecular imaging of Aβ accumulation and cortical metabolism. Significant associations were mapped onto large-scale networks, identified through an atlas and by knowledge, to elaborate on the reliability of the results. Plasma Aβ42/40 ratio was associated with Aβ-PET uptake (but not FDG-PET) in regions generally investigated in preclinical AD such as those belonging to the default mode network, but also in regions/networks normally not accounted - including the central executive and salience networks - which likely have a selective vulnerability to incipient Aβ accumulation.The present whole-brain approach is promising to investigate early pathophysiological changes of AD to fully capture the complexity of the disease, which is essential to develop timely screening, detection, diagnostic, and therapeutic interventions. |
Databáze: | OpenAIRE |
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