Some properties and possible biological role of peptidase inhibitors from the entomopathogenic fungus Tolypocladium cylindrosporum
| Autor: | Tatyana A. Semenova, G. A. Beliakova, V. I. Domash, Mikhail A. Belozersky, Yakov E. Dunaevsky, V. V. Popova |
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| Rok vydání: | 2015 |
| Předmět: |
biology
Molecular mass Hypocreales fungi Pseudomonas Proteolytic enzymes Subtilisin General Medicine Fungus biology.organism_classification Biochemistry Microbiology Anti-Bacterial Agents Enzymes Enzyme Activation Bacterial Proteins Entomopathogenic fungus Genetics Protease Inhibitors Molecular Biology Mycelium |
| Zdroj: | Archives of microbiology. 197(8) |
| ISSN: | 1432-072X |
| Popis: | The activities of secreted and mycelial inhibitors of proteolytic enzymes from fungi of the order Hypocreales have been investigated. Inhibitors of bromelain, papain, and trypsin of low molecular mass (about 1 kDa) and a subtilisin proteinaceous inhibitor with molecular mass of 45 kDa were revealed in the culture liquid of the fungus Tolypocladium cylindrosporum. The subtilisin inhibitor from T. cylindrosporum has antibiotic properties, significantly decreased the activity of purified bacterial enzymes, and prevented the growth of the bacterium Pseudomonas sp. Data suggesting the existence in fungi of the Hypocreales order of two pools of peptidase inhibitors have been obtained. |
| Databáze: | OpenAIRE |
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