Botulinum Neurotoxins: Still a Privilege of Clostridia?
| Autor: | Michel R. Popoff |
|---|---|
| Přispěvatelé: | Toxines bactériennes - Bacterial Toxins, Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Botulinum Toxins Hydrolases [SDV]Life Sciences [q-bio] Neurotoxins Privilege (computing) [SDV.BC]Life Sciences [q-bio]/Cellular Biology [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC] MESH: Neurotoxins Microbiology Article Clostridia 03 medical and health sciences 0302 clinical medicine Clostridium Virology [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] Humans MESH: Botulinum Toxins Microbial toxins MESH: Humans biology MESH: Clostridium biochemical phenomena metabolism and nutrition biology.organism_classification [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology 3. Good health MESH: Hydrolases 030104 developmental biology [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Parasitology 030217 neurology & neurosurgery |
| Zdroj: | Cell Host and Microbe Cell Host and Microbe, 2018, 23 (2), pp.145-146. ⟨10.1016/j.chom.2018.01.014⟩ Cell Host & Microbe Cell Host & Microbe, 2018, 23 (2), pp.145-146. ⟨10.1016/j.chom.2018.01.014⟩ Cell Host and Microbe, Elsevier, 2018, 23 (2), pp.145-146. ⟨10.1016/j.chom.2018.01.014⟩ |
| ISSN: | 1931-3128 |
| DOI: | 10.1016/j.chom.2018.01.014⟩ |
| Popis: | Botulinum neurotoxins (BoNTs), produced by various Clostridium strains, are a family of potent bacterial toxins and potential bioterrorism agents. Here we report that an Enterococcus faecium strain isolated from cow feces carries a BoNT-like toxin, designated BoNT/En. It cleaves both VAMP2 and SNAP-25, proteins that mediate synaptic vesicle exocytosis in neurons, at sites distinct from known BoNT cleavage sites on these two proteins. Comparative genomic analysis determines that the E. faecium strain carrying BoNT/En is a commensal-type, and the BoNT/En gene is located within a typical BoNT gene cluster on a 206-kb putatively conjugative plasmid. Although the host species targeted by BoNT/En remains to be determined, these findings establish an extended member of BoNTs and demonstrate the capability of E. faecium, a commensal organism ubiquitous in humans and animals and a leading cause of hospital-acquired multidrug resistant (MDR) infections, to horizontally acquire, and possibly disseminate, a unique BoNT gene cluster. |
| Databáze: | OpenAIRE |
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