Altered brain responses to specific negative emotions in schizophrenia
| Autor: | Teresa Maristany, Carmen Natividad, Jesus J. Gomar, Raymond Salvador, Alicia Valiente-Gómez, Amalia Guerrero-Pedraza, Salvador Sarró, María Ángeles García-León, Edith Pomarol-Clotet, Francisco Portillo, Jordi Ortiz-Gil, Silvia Alonso-Lana, Pilar Salgado-Pineda, Paola Fuentes-Claramonte, Joaquim Radua |
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| Přispěvatelé: | [Garcia-Leon MA, Fuentes-Claramonte P, Salgado-Pineda P] FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain. [Valiente-Gómez A] IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. [Natividad C] Hospital Mare de Déu de la Mercè, Barcelona, Spain. [Gomar JJ] Litwin-Zucker Alzheimer’s Disease Center, Feinstein Institute, Manhassett, NY, USA. [Guerrero-Pedraza A, Portillo F] Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain. [Ortiz-Gil J] Hospital General de Granollers, Granollers, Spain, Hospital General de Granollers |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Neuroestimulació
Cognitive Neuroscience media_common.quotation_subject Happiness Emotions Computer applications to medicine. Medical informatics R858-859.7 Stimulus (physiology) behavioral disciplines and activities IAPS Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Magnetic Resonance Imaging [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] mental disorders medicine Humans Radiology Nuclear Medicine and imaging diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::tomografía::imagen por resonancia magnética [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] RC346-429 Anterior cingulate cortex media_common Temporal cortex Brain Mapping técnicas de investigación::estimulación física::estimulación luminosa [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] fMRI Brain Regular Article medicine.disease Magnetic Resonance Imaging Disgust disciplinas y actividades conductuales::psicología del esquizofrénico [PSIQUIATRÍA Y PSICOLOGÍA] Sadness Facial Expression medicine.anatomical_structure Neurology Superior frontal gyrus Schizophrenia Mental Disorders::Personality Disorders::Schizotypal Personality Disorder [PSYCHIATRY AND PSYCHOLOGY] Esquizofrènia Neurology (clinical) Neurology. Diseases of the nervous system Psychology Investigative Techniques::Physical Stimulation::Photic Stimulation [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] Neuroscience Imatgeria per al diagnòstic psychological phenomena and processes Scenic stimuli |
| Zdroj: | NeuroImage: Clinical, Vol 32, Iss, Pp 102894-(2021) NeuroImage : Clinical Scientia |
| ISSN: | 2213-1582 |
| Popis: | Highlights • Scenic stimuli might offer a better understanding of emotional processing than faces. • Emotional scenes were presented to schizophrenia patients and healthy controls. • Schizophrenia patients tend to misclassify emotional images as fear. • Schizophrenia patients hyperactivated regions involved in fear and disgust processing. • Patients’ brain response did not differ from controls in response to happy and sad scenes. Deficits in emotion processing are a core feature of schizophrenia, but their neurobiological bases are poorly understood. Previous research, mainly focused on emotional face processing and emotion recognition deficits, has shown controverted results. Furthermore, the use of faces has been questioned for not entailing an appropriate stimulus to study emotional processing. This highlights the importance of investigating emotional processing abnormalities using evocative stimuli. For the first time, we have studied the brain responses to scenic stimuli in patients with schizophrenia. We selected scenes from the IAPS that elicit fear, disgust, happiness, and sadness. Twenty-six patients with schizophrenia and thirty age-, sex- and premorbid IQ-matched healthy controls were included. Behavioral task results show that patients tended to misclassify disgust and sadness as fear. Brain responses in patients were different from controls in images eliciting disgust and fear. In response to disgust images, patients hyperactivated the right temporal cortex, which was not activated by the controls. With fear images, hyperactivation was observed in brain regions involved in fear processing, including midline regions from the medial frontal cortex to the anterior cingulate cortex, the superior frontal gyrus, inferior and superior temporal cortex, and visual areas. These results suggest that schizophrenia is characterized by hyper-responsivity to stimuli evoking high-arousal, negative emotions, and a bias towards fear in emotion recognition. |
| Databáze: | OpenAIRE |
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