A history of ischemic heart disease is a common cause of wheezing in the elderly of a Japanese local community
| Autor: | Shigeki Sumi, Seisuke Okazawa, Minehiko Inomata, Chihiro Taka, Kazuyuki Tobe, Shoko Matsui, Minoru Iwata, Kensuke Suzuki, Yasuaki Masaki, Yukio Kawagishi, Kenta Kambara, Hideki Origasa, Tomomi Ichikawa, Ryuji Hayashi, Isao Usui, Shingo Imanishi, Kotaro Tokui, Toru Yamada |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Asian Continental Ancestry Group
Male Pediatrics medicine.medical_specialty Multivariate analysis Heart disease Cross-sectional study medicine.drug_class Myocardial Ischemia Disease Quality of life Asian People Japan Surveys and Questionnaires Natriuretic Peptide Brain Internal Medicine Natriuretic peptide Medicine Humans Asthma Aged Respiratory Sounds Aged 80 and over business.industry General Medicine social sciences Immunoglobulin E Middle Aged medicine.disease humanities Peptide Fragments Cross-Sectional Studies Quality of Life Female business Airway |
| Zdroj: | Internal medicine (Tokyo, Japan). 50(24):2975-2981 |
| ISSN: | 1349-7235 |
| Popis: | We conducted a cross-sectional study to investigate which factors have a significant impact on wheezing and QOL in the elderly of a Japanese local community. In 2008, 527 participants (250 participants aged 45 to 64 years and 277 participants aged 65 to 88 years) responded to the questionnaire regarding wheezing and disease history. QOL was evaluated by the Short Form-8. The participants underwent airway reversibility testing. The plasma levels of IgE were measured. The plasma levels of N-terminal-pro-B-type natriuretic peptide were measured in twenty-one participants with a history of ischemic heart disease and in thirty-five age-matched participants without that history. Wheezing was reported by 50 (9.5%) participants and was associated with a lower score of QOL. In multivariate analysis, wheezing was associated with sex (OR 3.12, CI 1.10-9.67) and a history of bronchial asthma (OR 22.3, CI 6.50-84.0) among participants aged 45 to 64 years. Among participants aged 65 and over, wheezing was associated with a history of bronchial asthma (OR 4.86, CI 1.39-15.1) and ischemic heart disease (OR 5.12, CI 1.61-15.0). Participants with both a history of ischemic heart disease and wheezing showed higher levels of N-terminal-pro-B-type natriuretic peptide. Airway reversibility was only associated with a history of ischemic heart disease (OR 4.65, CI 1.26-17.6). It is suggested that bronchial asthma and heart disease are both significant causes of wheezing and affect the QOL in the elderly of a Japanese local community. |
| Databáze: | OpenAIRE |
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