Invasive dermatophyte infection with Trichophyton interdigitale is associated with prurigo-induced pseudoperforation and a signal transducer and activator of transcription 3 mutation
| Autor: | Bodo Grimbacher, J.K. Simpson, Suranjith L. Seneviratne, David M. Lowe, L. Fearfield, P. Fröbel, Michael Brown, Manfred Fliegauf |
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| Rok vydání: | 2018 |
| Předmět: |
Male
STAT3 Transcription Factor 0301 basic medicine Antifungal Agents Biopsy DNA Mutational Analysis Dermatology Groin medicine.disease_cause Microbiology 03 medical and health sciences 0302 clinical medicine Trichophyton Dermis Loss of Function Mutation Prurigo medicine Dermatomycoses Humans 030212 general & internal medicine STAT3 Glucocorticoids Skin Mutation Innate immune system integumentary system biology Middle Aged biology.organism_classification medicine.disease Trichophyton interdigitale 030104 developmental biology medicine.anatomical_structure Dermatophyte STAT protein biology.protein Th17 Cells Tomography X-Ray Computed Invasive Fungal Infections |
| Zdroj: | British Journal of Dermatology. 179:750-754 |
| ISSN: | 0007-0963 |
| DOI: | 10.1111/bjd.15781 |
| Popis: | Invasive dermatophyte infection, with extension beyond the dermis, in immunocompetent hosts is exceptionally rare. Dermatophytes are keratinophilic and are usually confined to the stratum corneum, hair and nails. Susceptibility to dermatophyte infections is incompletely understood, but inherited mutations in key signalling pathways of the innate immune system have been identified. We report the first case of an invasive dermatophyte infection associated with abrupt onset of a prurigo-induced pseudoperforation and a loss-of-function mutation in signal transducer and activator of transcription 3 (STAT3). |
| Databáze: | OpenAIRE |
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