Mononuclear cell infiltrate and HLA-DR expression in low grade astrocytomas
| Autor: | F. F. Cruz-Sanchez, Margaret M. Esiri, Hugh B. Coakham, J. T. Hughes, Tim H. Moss, M. L. Rossi |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Cellular immunity Adolescent Lymphocyte Astrocytoma Peripheral blood mononuclear cell Pathology and Forensic Medicine Cellular and Molecular Neuroscience Antigen medicine HLA-DR Humans Macrophage Lymphocytes Child business.industry Macrophages HLA-DR Antigens T lymphocyte medicine.disease Immunohistochemistry medicine.anatomical_structure Female Neurology (clinical) business |
| Zdroj: | Acta Neuropathologica. 76:281-286 |
| ISSN: | 1432-0533 0001-6322 |
| DOI: | 10.1007/bf00687776 |
| Popis: | Frozen samples from 23 low grade (grade I and II) astrocytomas were studied by means of a panel of monoclonal antibodies to macrophages, lymphocytes (and their subsets) and HLA-DR antigens. Macrophages were present in low to moderate numbers in 38%-86% of cases, the variance in figures depending on the antibody used. T lymphocytes, the majority of CD8 phenotype, were detected in low numbers in 78% of tumours. B lymphocytes were scanty in 22% (5/22) and totally absent in the remaining cases. HLA-DR antigen was expressed by tumour cells in 35% (6/17) of cases. These findings indicate that in some low grade astrocytomas there is a mononuclear cell infiltrate with macrophages and secondarily CD8+ lymphocytes playing the major role. The significance of these findings remains speculative at present. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink