Food Matrix Effects on Bioaccessibility of β-Carotene Can be Measured in an in Vitro Gastrointestinal Model
| Autor: | Paul J.M. Hulshof, Carolien A. Van Loo-Bouwman, Gertjan Schaafsma, Richard B. van Breemen, Mans Minekus, Ton H. J. Naber |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
digestion method
in vitro digestion medicine.medical_treatment Biological Availability In Vitro Techniques Biology Models Biological cassava Article Intestinal absorption Matrix (chemical analysis) chemistry.chemical_compound Dietary Fats Unsaturated In vivo beta-Carotene β-carotene Vegetables medicine folic-acid Food science VLAG Global Nutrition Wereldvoeding Carotene Retinol General Chemistry beta Carotene bioaccessibility accessibility Diet Bioavailability Gastrointestinal Tract chemistry Food Dietary Supplements Digestion bioavailability General Agricultural and Biological Sciences absorption serum green leafy vegetables food matrix pro-vitamin retinol |
| Zdroj: | Journal of Agricultural and Food Chemistry Journal of Agricultural and Food Chemistry 62 (2014) 4 Journal of Agricultural and Food Chemistry, 62(4), 950-955 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf403312v |
| Popis: | Since the food matrix determines β-carotene availability for intestinal absorption, food matrix effects on the bioaccessibility of β-carotene from two diets were investigated in vitro and compared with in vivo data. The "mixed diet" consisted of β-carotene-rich vegetables, and the "oil diet" contained β-carotene-low vegetables with supplemental β-carotene. The application of extrinsically labeled β-carotene was also investigated. The bioaccessibility of β-carotene was 28 μg/100 μg β-carotene from the mixed diet and 53 μg/100 μg β-carotene from the oil diet. This ratio of 1.9:1 was consistent with in vivo data, where the apparent absorption was 1.9-fold higher in the oil diet than in the mixed diet. The labeled β-carotene was not equally distributed over time. In conclusion, the food matrix effects on bioaccessibility of β-carotene could be measured using an in vitro model and were consistent with in vivo data. The application of extrinsically labeled β-carotene was not confirmed. © 2014 American Chemical Society. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|