The bone marrow niche, stem cells, and leukemia: impact of drugs, chemicals, and the environment
| Autor: | David Ross, Robert Snyder, Jerry M. Rice, Debra A. Kaden, Richard A. Larson, Helmut Greim, Christine Palermo |
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| Rok vydání: | 2014 |
| Předmět: |
Stromal cell
General Neuroscience Niche Biology medicine.disease General Biochemistry Genetics and Molecular Biology Endothelial stem cell Haematopoiesis Leukemia medicine.anatomical_structure History and Philosophy of Science Cancer stem cell Immunology Cancer research medicine Bone marrow Aplastic anemia Stem cell |
| Zdroj: | Annals of the New York Academy of Sciences. 1310:1-6 |
| ISSN: | 0077-8923 |
| DOI: | 10.1111/nyas.12333 |
| Popis: | Detection, treatment, and prevention of bone marrow diseases have long been the aims of experimental and clinical hematologists and mechanistically oriented toxicologists. Among these diseases is aplastic anemia, which manifests as the cessation of normal blood cell production; the leukemias, in contrast, feature the production of excessive hematologic cancer cells. Both diseases are associated with exposure to either industrial chemicals or cancer chemotherapeutic agents. Studies of hematopoietic bone marrow cells in culture have shown that the generation of circulating blood cells requires the interaction of hematopoietic stem cells (HSCs) with supporting marrow stromal cells; yet, isolation of HSCs from bone destroys the unique morphology of the marrow stroma in which the HSCs reside. Imaging techniques and related studies have made it possible to examine specific niches where HSCs may either initiate differentiation toward mature blood cells or reside in a dormant state awaiting a signal to begin differentiation. HSCs and related cells may be highly vulnerable to the mutagenic or toxic effects of drugs or other chemicals early in these processes. Additional studies are required to determine the mechanisms by which drug or chemical exposure may affect these cells and lead to either depression of bone marrow function or to leukemia. |
| Databáze: | OpenAIRE |
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