Low levels of SIV-specific CD8+ T cells in germinal centers characterizes acute SIV infection

Autor:	Pamela J. Skinner, Eva G. Rakasz, Elizabeth Connick, Gwantwa Mwakalundwa, Reece K. Wagstaff, Joy M. Folkvord, Katalin J. Kovács, Shengbin Li, Aaron Rendahl
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	RNA viruses B Cells Simian Acquired Immunodeficiency Syndrome CD8-Positive T-Lymphocytes Virus Replication Pathology and Laboratory Medicine Pathogenesis White Blood Cells Immunodeficiency Viruses Animal Cells Follicular phase Medicine and Health Sciences Cytotoxic T cell Biology (General) Staining B-Lymphocytes 0303 health sciences T Cells 030302 biochemistry & molecular biology Cell Staining virus diseases Viral Load 3. Good health medicine.anatomical_structure SIV Medical Microbiology Viral Pathogens Acute Disease Viruses Infectious diseases Simian Immunodeficiency Virus Cellular Types Pathogens Anatomy Research Article HIV infections QH301-705.5 Immune Cells Immunology Cytotoxic T cells Viral diseases Biology Research and Analysis Methods Microbiology Lymphatic System 03 medical and health sciences Virology Retroviruses Genetics medicine Animals Antibody-Producing Cells Microbial Pathogens Molecular Biology B cell 030304 developmental biology Blood Cells Lentivirus Organisms Biology and Life Sciences Germinal center Cell Biology RC581-607 Germinal Center Macaca mulatta Viral Replication Chronic infection Perforin Specimen Preparation and Treatment biology.protein Parasitology Lymph Nodes Immunologic diseases. Allergy CD8
Zdroj:	PLoS Pathogens, Vol 15, Iss 3, p e1007311 (2019) PLoS Pathogens
ISSN:	1553-7374 1553-7366
Popis:	CD8+ T cells play an important role in controlling of HIV and SIV infections. However, these cells are largely excluded from B cell follicles where HIV and SIV producing cells concentrate during chronic infection. It is not known, however, if antigen-specific CD8+ T cells are excluded gradually as pathogenesis progresses from early to chronic phase, or this phenomenon occurs from the beginning infection. In this study we determined that SIV-specific CD8+ T cells were largely excluded from follicles during early infection, we also found that within follicles, they were entirely absent in 60% of the germinal centers (GCs) examined. Furthermore, levels of SIV-specific CD8+ T cells in follicular but not extrafollicular areas significantly correlated inversely with levels of viral RNA+ cells. In addition, subsets of follicular SIV-specific CD8+ T cells were activated and proliferating and expressed the cytolytic protein perforin. These studies suggest that a paucity of SIV-specific CD8+ T cells in follicles and complete absence within GCs during early infection may set the stage for the establishment of persistent chronic infection. Author summary A paucity of SIV-specific CD8+ T cells in lymphoid follicles and complete absence within most follicular germinal centers during early infection may set the stage for the establishment of persistent chronic infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d875b4e5c6327abe67bce43d6ad7517 https://doaj.org/article/6a88171ea935482787e47432a776917a Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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