Maternal obesity and baseline vitamin D insufficiency alter the response to vitamin D supplementation: a double-blind, randomized trial in pregnant women
| Autor: | Michael Parker, James J. Strain, Mary T McCann, Maria S. Mulhern, Raghad Alhomaid, Eamon Laird, Martin Healy |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Women's Nutrition medicine.medical_specialty Medicine (miscellaneous) vitamin D Umbilical cord law.invention Obesity Maternal AcademicSubjects/MED00160 AcademicSubjects/MED00060 body weight BMI chemistry.chemical_compound Double-Blind Method Randomized controlled trial Pregnancy law Internal medicine Vitamin D and neurology Humans vitamin D requirements Medicine Nutrition and Dietetics Dose-Response Relationship Drug Vitamin d supplementation business.industry Infant Newborn 25(OH)D concentration Fetal Blood Vitamin D Deficiency medicine.disease Obesity maternal obesity Original Research Communications medicine.anatomical_structure Endocrinology chemistry Dietary Supplements Gestation Female business Cholecalciferol |
| Zdroj: | The American Journal of Clinical Nutrition |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/nqab112 |
| Popis: | Background The achievement of target 25-hydroxyvitamin D [25(OH)D] concentrations in pregnancy may be altered by maternal obesity. Objective The authors examined the effects of maternal supplementation of 10 μg compared with 20 μg vitamin D3/d on maternal and umbilical cord 25(OH)D. The secondary aim was to investigate the influence of maternal BMI (in kg/m2) on the response of the primary outcomes. Methods The authors performed a 2-arm parallel double-blind randomized trial with 240 pregnant women recruited throughout the year in Northern Ireland. Women were stratified by BMI to receive 10 or 20 µg vitamin D3/d from 12 gestational wk (GW) until delivery. Maternal blood samples collected at 12, 28, and 36 GW and from the umbilical cord were analyzed for total serum 25(OH)D. A total of 166 women completed the study. Results Mean ± SD 25(OH)D at 36 GW was 80.8 ± 28.2 compared with 94.4 ± 33.2 nmol/L (P < 0.001) (10 compared with 20 µg vitamin D3/d, respectively). In those classified with 25(OH)D |
| Databáze: | OpenAIRE |
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