The Relationship of Race, Oncotype DX, and Ki67 in a Population Highly Screened For Breast Cancer
| Autor: | Amber A. Guth, Jennifer Montes, Rebecca Akiko Snyder, Deborah Axelrod, Shira Schwartz, Jennifer Chun Kim, Freya Schnabel |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine Oncology medicine.medical_specialty Receptor ErbB-2 Population Breast Neoplasms Triple Negative Breast Neoplasms White People Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Biomarkers Tumor Internal Medicine Carcinoma Humans Medicine Stage (cooking) Young adult education Aged Aged 80 and over Gynecology education.field_of_study medicine.diagnostic_test business.industry Carcinoma Ductal Breast Middle Aged medicine.disease Black or African American Ki-67 Antigen 030104 developmental biology 030220 oncology & carcinogenesis Cohort Female Surgery Neoplasm Recurrence Local business Oncotype DX Mammography Cohort study |
| Zdroj: | The Breast Journal. 23:177-181 |
| ISSN: | 1075-122X |
| Popis: | Oncotype DX recurrence score (ODX) can predict risk of invasive breast cancer recurrence and benefit of chemotherapy. Literature is limited on the relationship of ODX and race in women with hormone receptor positive and node negative/positive disease. Our study examines the relationship between race and clinical characteristics within a population of highly screened women with newly diagnosed breast cancer. The institutional Breast Cancer Database was queried for patients with newly diagnosed breast cancer between January2010 and March2015. We analyzed clinical and tumor characteristics including ODX. Statistical analyses included Pearson's Chi-Square and Fisher's Exact Tests. There were 2,092 women in our study cohort. The majority had college-level education (84%), regular screening (78%), and clinical breast exams (88%). The majority had invasive ductal carcinoma (IDC) (62%), early stage (0, I, II) tumors (93%), ER+ (84%), PR+ (71%), Her2 negative (86%), and node negative disease (83%). There was a significantly higher proportion of later stage disease among African-Americans (p = 0.001) and Asians (p = 0.006) and more triple negative breast cancers among African-Americans (p |
| Databáze: | OpenAIRE |
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