Comparison between electronic cigarette refill liquid and nicotine on metabolic parameters in rats
| Autor: | Ines Bini-Dhouib, Narges El Golli, Monia Allal-El Asmi, Yosra Dallagi, Houssem Dkhili, Jean-Philippe Rosa, Dalila Rahali, M Lebret, Montassar Lasram, Saloua El Fazaa |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Nicotine NICOTINE EXPOSURE Electronic Nicotine Delivery Systems Pharmacology Weight Gain General Biochemistry Genetics and Molecular Biology law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Liver Function Tests law medicine Animals Glucose homeostasis Nicotinic Agonists 030212 general & internal medicine Rats Wistar General Pharmacology Toxicology and Pharmaceutics medicine.diagnostic_test Cholesterol Cholesterol LDL General Medicine Lipid Metabolism Rats 030104 developmental biology Liver chemistry Toxicity Phosphoenolpyruvate carboxykinase Lipid profile Electronic cigarette Biomarkers Glycogen Injections Intraperitoneal medicine.drug |
| Zdroj: | Life Sciences. 146:131-138 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2015.12.049 |
| Popis: | Aims Nicotine is known to promote body weight loss and to disturb glucose homeostasis and lipoprotein metabolism. Electronic cigarettes, as a substitute to nicotine, are becoming increasingly popular, although there is no evidence regarding their safety. Considering the dearth of information about e-cigarette toxicity, the present study was designed to compare nicotine alone to e-liquid with or without nicotine on metabolic parameters in Wistar rats. Main methods For this purpose, e-liquid with or without nicotine and nicotine alone (0.5 mg/kg of body weight) were administered intra-peritoneally during 28 days. Key findings Our results show a significant decrease in food and energy intake after nicotine or e-liquid with nicotine exposure, when compared to control or e-liquid without nicotine. Analysis of lipid status identified a significant decrease in cholesterol and LDL levels in e-cigarette groups, suggesting an improvement in lipid profile. Interestingly, e-liquid without nicotine induced hyperglycemia which is negatively correlated to hepatic glycogen level, acting like nicotine alone. Furthermore, an increase in liver biomarkers was observed in all treated groups. qRT-PCR analysis showed GSK3β up-regulation in e-liquid with nicotine as well as, surprisingly, in e-liquid without nicotine exposure. In contrast, PEPCK genes were only up-regulated in e-liquid with nicotine. Significance While some features observed in rats may not be observed in human smokers, most of our data are consistent with, e-liquid per se i.e. without nicotine, not being neutral from a metabolic stand point since disrupting glucose homeostasis in rats. |
| Databáze: | OpenAIRE |
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