Testosterone inhibits prostaglandin formation by human gingival connective tissue: Relationship to 14C-arachidonic acid metabolism
| Autor: | Daniel E. Tira, Tawfik M.A. Elattar, H.S. Lin |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Physiology Gingiva Connective tissue Arachidonic Acids Prostaglandin formation Biology Inhibitory postsynaptic potential Biochemistry Cyclooxygenase pathway Endocrinology Internal medicine medicine Humans Testosterone Arachidonic Acid Dose-Response Relationship Drug Arachidonic acid metabolism medicine.anatomical_structure Connective Tissue Sex steroid Prostaglandins lipids (amino acids peptides and proteins) Hormone |
| Zdroj: | Prostaglandins, Leukotrienes and Medicine. 9:25-34 |
| ISSN: | 0262-1746 |
| DOI: | 10.1016/0262-1746(82)90069-5 |
| Popis: | The relationship between various concentrations of the male sex steroid, testosterone and the formation of radioactive prostaglandins (PGs) from 14C-arachidonic acid by human gingival homogenate has been investigated. There were statistically significant (combined) linear and quadratic tends between hormone treatment at concentrations of 10−9, 10−7, 10−5 and 10−3M and the amounts of PGF2a PGE2, PGD2 and 15-keto-PGE2 formed. The mean amount of each PG formed at the various concentrations of testosterone was statistically significantly less than the corresponding control level. The results indicate that testosterone, at the dose levels tested, is inhibitory to the cyclooxygenase pathway of arachidonic acid metabolism in gingiva. |
| Databáze: | OpenAIRE |
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