In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae
| Autor: | Kevin Pettus, Cau D. Pham, Tara C. Henning, Ellen N. Kersh, Samera Sharpe, Evelyn E. Nash |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) 030106 microbiology Microbial Sensitivity Tests Drug resistance Azithromycin medicine.disease_cause Article Microbiology 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Boric Acids medicine 030212 general & internal medicine Edetic Acid Chemistry Broth microdilution Drug Synergism General Medicine Antimicrobial Neisseria gonorrhoeae Anti-Bacterial Agents Penicillin Ciprofloxacin Infectious Diseases bacteria medicine.drug |
| Zdroj: | Diagnostic Microbiology and Infectious Disease. 93:369-371 |
| ISSN: | 0732-8893 |
| Popis: | Neisseria gonorrhoeae quickly develops drug resistance. Time-kill curves revealed that EDTA and TOL-463 inhibit growth similar to penicillin, ciprofloxacin, and azithromycin. Furthermore, synergistic and additive antimicrobial interactions occurred when EDTA and TOL-463 were combined with penicillin or azithromycin, respectively, suggesting that further investigations into these unconventional antimicrobials may be advantageous. |
| Databáze: | OpenAIRE |
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