Urinary neutrophil-gelatinase associated lipocalin is a more prognostic biomarker to distinguish antenatal hydronephrosis in neonates
| Autor: | Araz Mohammad Mirabi, Abdolrasul Aalaee, Alireza Rafiei, Mohammad Abedi, Hamid Mohammadjafari, Ehsan Abedi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Urinary system Antenatal hyronephrosis Urology Urine Vesicoureteral reflux chemistry.chemical_compound Neonate medicine Antenatal Hydronephrosis NGAL Hydronephrosis Creatinine lcsh:R5-920 Receiver operating characteristic business.industry Case-control study General Medicine medicine.disease Surgery chemistry business lcsh:Medicine (General) |
| Zdroj: | Research in Molecular Medicine, Vol 1, Iss 2, Pp 10-16 (2013) |
| ISSN: | 2322-1348 |
| Popis: | Background and Aim: Routine diagnostic methods of Vesicoureteral reflu x (VUR) are invasive and can cause exposure to radiat ion and may increase risk of urinary tract infections. Therefore, introducing re liable, non invasive methods might be more interested in pediatric nephrology. T he objective of this perospective case control study was to evaluate the prognostic value of urinary neutrophil-gelatinase associated lipocalin (uNGAL) on antenatal hydronephrosis (AH) with and without VUR. Methods: A total of 50 patients diagnosed with AH; 78% males with mean age 5.71± 2.1 years, including 27 AH with VUR and 23 AH without VUR, and 19 normal healthy children; 78.9% males with mean age 5.63 ± 1.89 years, were enrolled in this study. Urinary NGAL levels were measured by enzyme linked immunosorbent assay (ELISA). Results: There was a significant difference in uNGAL concentration between AH patients and controls (0.80 ± 0.26 and 0.29 ± 0. 27 ng/ml, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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