Effect of magnesium sulphate in patients with unstable angina: A double blind, randomized, placebo-controlled study
| Autor: | Simon Redwood, Y Bashir, Juan Carlos Kaski, A. J. Camm, Jian Huang, E Leatham |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiotonic Agents Myocardial Ischemia Placebo-controlled study chemistry.chemical_element Creatine Placebo Statistics Nonparametric Excretion Magnesium Sulfate chemistry.chemical_compound Catecholamines Double-Blind Method Heart Conduction System medicine Humans Angina Unstable Infusions Intravenous Creatine Kinase Aged Aged 80 and over Creatinine biology business.industry Magnesium Unstable angina Middle Aged medicine.disease Surgery Isoenzymes Treatment Outcome chemistry Anesthesia Electrocardiography Ambulatory biology.protein Female Creatine kinase Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Heart Journal. 18:1269-1277 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/oxfordjournals.eurheartj.a015438 |
| Popis: | Aim Administration of intravenous magnesium sulphate has been shown to be protective during acute myocardial ischaemia and it may therefore have beneficial effects in unstable angina. The purpose of this study was to assess the effects of a 24-h infusion of magnesium in patients with unstable angina. Methods and results Patients who presented with unstable angina with electrocardiographic changes were randomized to receive a 24-h intravenous infusion of magnesium or placebo within 12 h of admission. The primary endpoint was myocardial ischaemia, as assessed by 48 h Holter monitoring. Resting 12-lead ECGs, creatine kinase-MB release and urinary catecholamines were also assessed. Patients were followed for 1 month. Thirty-one patients received magnesium sulphate and 31 placebo. Baseline characteristics and extent of coronary disease were similar in both groups. On 48 h Holter monitoring, 14 patients (50%) had transient ST segment shifts in the magnesium group vs 12 patients (46%) in the placebo group. However, there were fewer ischaemic episodes in the magnesium group (51 vs 101, P |
| Databáze: | OpenAIRE |
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