alpha-Melanocyte-stimulating hormone (alpha-MSH) and melanin-concentrating hormone (MCH) modify monoaminergic levels in the preoptic area of the rat
| Autor: | Maria Isabel Gonzalez, V. Kalia, D. R. Hole, Catherine A. Wilson |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Melanocyte-stimulating hormone Melanin-concentrating hormone Physiology Microdialysis Serotonergic Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Dopamine Internal medicine Monoaminergic medicine Animals Biogenic Monoamines Rats Wistar Melanins Hypothalamic Hormones Chemistry Dopaminergic Infusion Pumps Implantable Preoptic Area Rats Preoptic area Pituitary Hormones Ventromedial Hypothalamic Nucleus alpha-MSH Female hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| Zdroj: | Peptides. 18(3) |
| ISSN: | 0196-9781 |
| Popis: | Gonzalez, M. I., V. Kalia, D. R. Hole and C. A. Wilson. α -Melanocyte-stimulating hormone ( α -MSH) and melanin-concentrating hormone (MCH) modify monoaminergic levels in the preoptic area of the rat. Peptides 18(3) 387–392, 1997.—The effect of perfusion of melanin-concentrating hormone (MCH) or α -melanocyte-stimulating hormone ( α -MSH) (100 ng/ μ l) in the ventromedial nucleus (VMN) or medial preoptic area (MPOA) on monoaminergic levels of female rats was measured using microdialysis and HPLC-electrochemical detection. In the MPOA, α -MSH raised 5-HIAA concentration, whereas MCH reduced both 5-HT and 5-HIAA. Neither peptide had any effect in the VMN. The opposite effects of the peptides on the serotonergic system might be responsible for their antagonistic or opposite actions previously reported on several CNS functions. Dopamine may mediate the similar effects of the two peptides, because α -MSH inhibits dopaminergic release in the MPOA (but not VMN) and MCH tends to follow the same pattern. |
| Databáze: | OpenAIRE |
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