Short-Term Consumption of Cuban Policosanol Lowers Aortic and Peripheral Blood Pressure and Ameliorates Serum Lipid Parameters in Healthy Korean Participants: Randomized, Double-Blinded, and Placebo-Controlled Study
| Autor: | Kyung-Hyun Cho, Suk-Jeong Kim, Da-Jeong Jeong, Hye-Jeong Park, Myung Ae Bae, Dhananjay Yadav, Jae-Ryong Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male high-density lipoproteins medicine.medical_specialty Mean arterial pressure Health Toxicology and Mutagenesis Placebo-controlled study Diastole lcsh:Medicine 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Placebo Gastroenterology Prehypertension Article 03 medical and health sciences Young Adult 0302 clinical medicine Asian People Double-Blind Method Internal medicine medicine low-density lipoproteins Humans Policosanol Antihypertensive Agents Aged business.industry Anticholesteremic Agents lcsh:R Public Health Environmental and Occupational Health policosanol Repeated measures design blood pressure Middle Aged Lipids Blood pressure Female Fatty Alcohols business medicine.drug |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 16, Iss 5, p 809 (2019) International Journal of Environmental Research and Public Health Volume 16 Issue 5 |
| ISSN: | 1660-4601 |
| Popis: | The current study was designed to investigate the short-term effects of policosanol consumption on blood pressure (BP) and the lipid parameters in healthy Korean participants with prehypertension. A total of 84 healthy participants were randomly allocated to three groups receiving placebo, 10 mg of policosanol, or 20 mg of policosanol for 12 weeks. Based on an average of three measurements of peripheral BP, the policosanol 20 mg group exhibited the most significant reduction, that is, up to 7.7% reduction of average systolic BP (SBP) from 136.3 ± 6.1 mmHg (week 0) to 125.9 ± 8.6 mmHg (week 12, p < 0.001). Between group comparisons using repeated measures ANOVA showed that the policosanol 20 mg group had a significant reduction of SBP at 12 weeks (p = 0.020) and a reduction of diastolic BP (DBP) at 8 weeks (p = 0.041) and 12 weeks (p = 0.035). The policosanol 10 mg and 20 mg groups showed significant reductions in aortic SBP of 7.4% and 8.3%, respectively. The policosanol groups showed significant reductions of total cholesterol (TC) of 9.6% and 8.6% and low-density lipoproteins (LDL-C) of 21% and 18% for 10 mg and 20 mg of policosanol, respectively. Between group comparisons using repeated measures ANOVA showed that the policosanol (10 mg and 20 mg) groups at 12 weeks had a significant reduction of TC (p = 0.0004 and p = 0.001) and LDL-C (p = 0.00005 and p = 0.0001) and elevation of %HDL-C (p = 0.048 and p = 0.014). In conclusion, 12-week consumption of policosanol resulted in significant reductions of peripheral SBP and DBP, aortic SBP and DBP, mean arterial pressure (MAP), and serum TC and LDL-C with elevation of % HDL-C. |
| Databáze: | OpenAIRE |
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