Generation of a human iPSC line CIBi007-A from a patient with young-onset Parkinson’s disease carrying variants in PRKN and HTRA2
| Autor: | Yan Yubo, Liu Yuqing, Bo Yang, Jiang Lixiang, Hui Ning, Fu Jian, Jiayin Yang, Jin Yu, Suihan Wu, Baorong Yu, Meng Chu, Xuhui Chen |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Disease mechanisms Karyotype Cell Biology General Medicine Disease Germ layer Young onset Parkinson's disease Biology Embryonic stem cell 03 medical and health sciences 030104 developmental biology 0302 clinical medicine lcsh:Biology (General) Cancer research Induced pluripotent stem cell lcsh:QH301-705.5 Ipsc line 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Stem Cell Research, Vol 47, Iss, Pp 101905-(2020) |
| ISSN: | 1873-5061 |
| Popis: | Variations in PRKN or HTRA2 are associated with Parkinson’s disease. We generated a human induced pluripotent stem cell (iPSC) line CIBi007-A from a patient with young-onset Parkinson’s disease (YOPD) who carried variants in PRKN and HTRA2. The generated iPSCs resembled human embryonic stem cells, expressed pluripotency markers, exhibited a normal karyotype, and could be differentiated into three germ layers in vitro. This line will be valuable for investigating disease mechanisms of YOPD and screening candidate drugs. |
| Databáze: | OpenAIRE |
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