Early production of proinflammatory cytokines in response to Scedosporium apiospermum during murine pulmonary infection

Autor:	Carolina E. Luna-Rodríguez, Gloria M. González, Orlando E. Flores-Maldonado, Rogelio Treviño-Rangel, Adrián G. Rosas-Taraco, Miguel A. Becerril-García
Rok vydání:	2022
Předmět:	Mice Antifungal Agents Infectious Diseases Mycoses Animals Cytokines Pneumonia Scedosporium Lung Microbiology
Zdroj:	Microbial Pathogenesis. 170:105718
ISSN:	0882-4010
DOI:	10.1016/j.micpath.2022.105718
Popis:	Scedosporium apiospermum is an opportunistic pathogen that can cause pulmonary infections in both immunosuppressive and immunocompetent patients. Cytokines are molecules that mediate the immune response to promote or eliminate fungal infections. In this work, we evaluated the cytokines profile in the lung and serum of mice infected with Scedosporium apiospermum. We found early production of IL-6, IL-1β and TNF-α cytokines in the lung of infected mice during the first 5 days of infection. We suggest that release of pro-inflammatory cytokines could play a role in the control of fungal invasion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d717a3d6075f7d50b2f8a7d5f59c6b7 https://doi.org/10.1016/j.micpath.2022.105718 Zobrazit plný text záznamu Full Text from ScienceDirect