Progressive galactose cataractogenesis and regional susceptibility in the neonatal lens
| Autor: | Annette Beyer-Mears, Patricia N. Farnsworth, Patricia A. Burke, S.-C. Joseph Fu |
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| Rok vydání: | 1978 |
| Předmět: |
Time Factors
Posterior parietal cortex Biology Cataract Cellular and Molecular Neuroscience chemistry.chemical_compound Cortex (anatomy) Lens Crystalline medicine Animals Inositol Fiber Galactitol Capsule Galactose Anatomy eye diseases Sensory Systems Lens Fiber Rats Ophthalmology medicine.anatomical_structure chemistry Animals Newborn Microscopy Electron Scanning Nucleus |
| Zdroj: | Experimental eye research. 27(3) |
| ISSN: | 0014-4835 |
| Popis: | Cortical fiber development in the neonatal rat lens was affected in offspring nursed for their first 20 days by mother rats placed on a 50% galactose diet. Scanning electron micrographs from five regions of the cataractous lenses were compared with matching regions of normal neonatal lenses of the same age. Fiber changes within each region were quantitated. The onset of the neonatal galactose cataract appeared at 7 days in the superficial anterior cortex (0–200 μm from the capsule) and progressed to the supranuclear anterior cortex (200–500 μm from the capsule) and superficial posterior cortex (0–200 μm from the capsule) by day 12 of the nursing period. By 20 days, the posterior supranuclear cortex (200–500 μm from the capsule) and nucleus showed alterations. Despite the region, individual fiber cataractogenesis progressed in the following sequence. (1) At the onset, the fiber failed to develop the normal number of interdigitations. (2) Portions of the cell, primarily the region between the interdigitations, became granulated. (3) Adjacent to the granulated segment, lacunae formed. (4) As granulation progressed, the fiber swelled. (5) Fewer interdigitations remained which allowed the lacunae to elongate and form intercellular clefts. (6) The parallel orientation of the fiber remnants was lost and replaced by amorphous material and large cavities. At the end of the 20-day nursing period, lens fibers in the anterior superficial cortex had completed all these changes while those in the posterior supranuclear cortex exhibited only the first. The progression of fiber cataractogenesis was correlated to the lenticular galactitol, galactose, glucose and inositol concentrations and cortical vacuolation was monitored with the slit-lamp. |
| Databáze: | OpenAIRE |
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