Effect of short-term DHEA administration on liver metabolism of lean and obese rats
| Autor: | Pamarthi F. Mohan, Margot P. Cleary |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Saccharomyces cerevisiae Proteins Physiology Cellular respiration medicine.drug_class Endocrinology Diabetes and Metabolism Dehydroepiandrosterone Biology Eating Oxygen Consumption Malate Dehydrogenase Physiology (medical) Internal medicine Coenzyme A Ligases Brown adipose tissue Respiration polycyclic compounds medicine Animals Coenzyme A Malic enzyme activity Obesity chemistry.chemical_classification Body Weight Fatty acid Organ Size Metabolism Androgen Rats Rats Zucker Repressor Proteins medicine.anatomical_structure Endocrinology Adipose Tissue Liver chemistry hormones hormone substitutes and hormone antagonists |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 255:E1-E8 |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.1988.255.1.e1 |
| Popis: | Lean and obese Zucker rats, 7-8 wk of age, were treated with dehydroepiandrosterone (DHEA) for either 3 or 7 days to determine the initial cellular event(s) that might be responsible for the antiobesity activity of DHEA. Epididymal, retroperitoneal, and brown adipose tissue weights were unaltered by either 3 or 7 days of DHEA treatment. Liver weight was not affected by 3 days of treatment but was 13 and 18% higher in 7-day DHEA-treated lean and obese rats, respectively, compared with their corresponding control group. Mitochondrial state 3 respiration rates with glutamate-malate and succinate as substrates were elevated by an average of 35% in 3- and 7-day DHEA-treated obese rats and by 15-20% in 7-day DHEA-treated lean rats compared with rates obtained in the corresponding control groups. State 3 respiration was not affected in 3-day DHEA-treated lean rats compared with control lean rats. The specific activities of long-chain fatty acyl-coenzyme A synthase and hydrolase and the levels of free CoA were increased by severalfold in cellular fractions of both DHEA-treated lean and obese rats compared with their respective control group. Hepatic malic enzyme activity, which was shown earlier to be elevated with long-term DHEA treatment, was unaltered by either 3 or 7 days of DHEA administration. The above results suggest the involvement of mitochondrial respiration and fatty acid deacylation/reacylation in the antiobesity mechanism of action of DHEA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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