Novel temperature and pH dual-sensitive PNIPAM/CMCS/MWCNT semi-IPN nanohybrid hydrogels: Synthesis, characterization, and DOX drug release
| Autor: | Jing-Yu Fu, Ya-Shao Chen, Yan-Ling Luo, Feng Xu, Xue-Yin Zhang |
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| Rok vydání: | 2017 |
| Předmět: |
Nanotube
Materials science Polymers and Plastics General Chemical Engineering Chemical structure technology industry and agriculture 02 engineering and technology macromolecular substances 010402 general chemistry 021001 nanoscience & nanotechnology Multiwalled carbon 01 natural sciences Anticancer drug 0104 chemical sciences Analytical Chemistry Chemical engineering Carboxymethyl-chitosan Self-healing hydrogels Polymer chemistry medicine Drug release Swelling medicine.symptom 0210 nano-technology |
| DOI: | 10.6084/m9.figshare.4046553.v2 |
| Popis: | Novel poly(N-isopropylacrylamide)/carboxymethyl chitosan/multiwalled carbon nanotube semi-interpenetrating nanohybrid hydrogels were prepared, and the chemical structure and morphology were characterized. The prepared hydrogels showed temperature and pH dual-responsiveness, and the one containing multiwalled carbon nanotubes (MWCNTs)–COOH possessed high maximal swelling ratios. The phase transition produced at pH of 6.8–7.4 and temperature of 35–40°C, hinging on the system compositions and charge ratios. The hydrogels were used to load hydrophilic anticancer drug, with high entrapped efficiency of about 44%. The drug release changed with temperature, pH, and MWCNTs–COOH contents. The designed hydrogels can be used for site-specific target delivery of protein or hydrophilic anticancer drug. |
| Databáze: | OpenAIRE |
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