Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium

Autor: Xiang-Zhen Kong, Premika S.W. Boedhoe, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Paul D. Arnold, Francesca Assogna, Justin T. Baker, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Brian P. Brennan, Jan Buitelaar, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Sara Dallaspezia, Damiaan Denys, Benjamin A. Ely, Jamie Feusner, Kate D. Fitzgerald, Jean-Paul Fouche, Egill A. Fridgeirsson, David C. Glahn, Patricia Gruner, Deniz A. Gürsel, Tobias U. Hauser, Yoshiyuki Hirano, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Anthony James, Fern Jaspers-Fayer, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Masaru Kuno, Gerd Kvale, Jun Soo Kwon, Luisa Lazaro, Yanni Liu, Christine Lochner, Paulo Marques, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, Sarah E. Medland, José M. Menchón, Luciano Minuzzi, Pedro S. Moreira, Astrid Morer, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Joseph O'Neill, Jose C. Pariente, Chris Perriello, John Piacentini, Fabrizio Piras, Federica Piras, Christopher Pittenger, Y.C. Janardhan Reddy, Oana Georgiana Rus-Oswald, Yuki Sakai, Joao R. Sato, Lianne Schmaal, H. Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Emily R. Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, David F. Tolin, Aki Tsuchiyagaito, Daan van Rooij, Guido A. van Wingen, Ganesan Venkatasubramanian, Zhen Wang, Je-Yeon Yun, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Clyde Francks, Alan Anticevic, Nerisa Banaj, Nuria Bargalló, Daniel Brandeis, Geraldo F. Busatto, Anna Calvo, Valentina Ciullo, Froukje E. de Vries, Stella J. de Wit, Erin Dickie, Renate Drechsler, Madalena Esteves, Andrea Falini, Yu Fang, Martijn Figee, Martine Fontaine, Geoff Hall, Sayo Hamatani, Gregory L. Hanna, Bjarne Hansen, Keisuke Ikari, Neda Jahanshad, Ricardo Magalhães, Yasutaka Masuda, Koji Matsumoto, James T. McCracken, Euripedes C. Miguel, Jin Narumoto, Seiji Nishida, Sara Poletti, Tim Reess, Eiji Shimizu, Nuno Sousa, Jumpei Takahashi, Jinsong Tang, Anders Lillevik Thorsen, Ysbrand D. van der Werf, Dick J. Veltman, Daniela Vecchio, Susanne Walitza, Anri Watanabe, Jian Xu, Xiufeng Xu, Kei Yamada, Tokiko Yoshida, Mojtaba Zarei, Qing Zhao, Cong Zhou
Přispěvatelé: ENIGMA-OCD Working Group, Adult Psychiatry, ANS - Compulsivity, Impulsivity & Attention, Graduate School, Child Psychiatry, Kong, X. -Z., Boedhoe, P. S. W., Abe, Y., Alonso, P., Ameis, S. H., Arnold, P. D., Assogna, F., Baker, J. T., Batistuzzo, M. C., Benedetti, F., Beucke, J. C., Bollettini, I., Bose, A., Brem, S., Brennan, B. P., Buitelaar, J., Calvo, R., Cheng, Y., Cho, K. I. K., Dallaspezia, S., Denys, D., Ely, B. A., Feusner, J., Fitzgerald, K. D., Fouche, J. -P., Fridgeirsson, E. A., Glahn, D. C., Gruner, P., Gursel, D. A., Hauser, T. U., Hirano, Y., Hoexter, M. Q., Hu, H., Huyser, C., James, A., Jaspers-Fayer, F., Kathmann, N., Kaufmann, C., Koch, K., Kuno, M., Kvale, G., Kwon, J. S., Lazaro, L., Liu, Y., Lochner, C., Marques, P., Marsh, R., Martinez-Zalacain, I., Mataix-Cols, D., Medland, S. E., Menchon, J. M., Minuzzi, L., Moreira, P. S., Morer, A., Morgado, P., Nakagawa, A., Nakamae, T., Nakao, T., Narayanaswamy, J. C., Nurmi, E. L., O'Neill, J., Pariente, J. C., Perriello, C., Piacentini, J., Piras, F., Pittenger, C., Reddy, Y. C. J., Rus-Oswald, O. G., Sakai, Y., Sato, J. R., Schmaal, L., Simpson, H. B., Soreni, N., Soriano-Mas, C., Spalletta, G., Stern, E. R., Stevens, M. C., Stewart, S. E., Szeszko, P. R., Tolin, D. F., Tsuchiyagaito, A., van Rooij, D., van Wingen, G. A., Venkatasubramanian, G., Wang, Z., Yun, J. -Y., Anticevic, A., Banaj, N., Bargallo, N., Brandeis, D., Busatto, G. F., Calvo, A., Ciullo, V., de Vries, F. E., de Wit, S. J., Dickie, E., Drechsler, R., Esteves, M., Falini, A., Fang, Y., Figee, M., Fontaine, M., Hall, G., Hamatani, S., Hanna, G. L., Hansen, B., Ikari, K., Jahanshad, N., Magalhaes, R., Masuda, Y., Matsumoto, K., Mccracken, J. T., Miguel, E. C., Narumoto, J., Nishida, S., Poletti, S., Reess, T., Shimizu, E., Sousa, N., Takahashi, J., Tang, J., Thorsen, A. L., van der Werf, Y. D., Veltman, D. J., Vecchio, D., Walitza, S., Watanabe, A., Xu, J., Xu, X., Yamada, K., Yoshida, T., Zarei, M., Zhao, Q., Zhou, C., Thompson, P. M., Stein, D. J., van den Heuvel, O. A., Francks, C., Netherlands Institute for Neuroscience (NIN), Universidade do Minho, Anatomy and neurosciences, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Psychiatry
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Adult
medicine.medical_specialty
Obsessive-Compulsive Disorder
Mega-analysis
Mega-analysi
media_common.quotation_subject
Thalamus
Medicina Básica [Ciências Médicas]
Audiology
Asymmetry
behavioral disciplines and activities
03 medical and health sciences
0302 clinical medicine
Neuroimaging
mental disorders
medicine
Image Processing
Computer-Assisted
Obsessive-compulsive disorder
Brain asymmetry
Humans
Child
Biological Psychiatry
Depression (differential diagnoses)
media_common
Brain Mapping
Science & Technology
medicine.diagnostic_test
business.industry
Laterality
Neurosi obsessiva
Brain
Magnetic resonance imaging
Cerebral cortex
Magnetic Resonance Imaging
humanities
Escorça cerebral
030104 developmental biology
Meta-analysis
Ciências Médicas::Medicina Básica
Pallidum
Anxiety
medicine.symptom
business
030217 neurology & neurosurgery
Zdroj: Kong, X-Z, Boedhoe, P S W, Abe, Y, Alonso, P, Ameis, S H, Arnold, P D, Assogna, F, Baker, J T, Batistuzzo, M C, Benedetti, F, Beucke, J C, Bollettini, I, Bose, A, Brem, S, Brennan, B P, Buitelaar, J, Calvo, R, Cheng, Y, Cho, K I K, Dallaspezia, S, Denys, D, Ely, B A, Feusner, J, Fitzgerald, K D, Fouche, J-P, Fridgeirsson, E A, Glahn, D C, Gruner, P, Gürsel, D A, Hauser, T U, Hirano, Y, Hoexter, M Q, Hu, H, Huyser, C, James, A, Jaspers-Fayer, F, Kathmann, N, Kaufmann, C, Koch, K, Kuno, M, Kvale, G, Kwon, J S, Schmaal, L, de Vries, F E, de Wit, S J, Figee, M, Thorsen, A L, van der Werf, Y D, Veltman, D J, van den Heuvel, O A, Francks, C & ENIGMA OCD Working Group 2020, ' Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium ', Biological Psychiatry, vol. 87, no. 12, pp. 1022-1034 . https://doi.org/10.1016/j.biopsych.2019.04.022
Biological Psychiatry
Dipòsit Digital de la UB
Universidad de Barcelona
Biological psychiatry, 87(12), 1022-1034. Elsevier USA
Biological Psychiatry, 87, 1022-1034. Elsevier USA
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Biological Psychiatry, 87(12), 1022-1034. Elsevier USA
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2019.04.022
Popis: Accepted Manuscript
BACKGROUND: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD.METHODS: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status.RESULTS: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = -20.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets.CONCLUSIONS: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.
This research was funded by the Max Planck Society (Germany). Additional funding was from the Japan Society for the Promotion of Science (KAKENHI Grant No. 18K15523 [to YA], KAKENHI Grant No. 16K04344 [to YH], KAKENHI Grant Nos. 16K19778 and 18K07608 [to TNakam], and KAKENHI Grant No. 26461762 [to AN]); the Carlos III Health Institute (Grant No. PI14/00419 [to PA], Grant No. PI040829 cofunded by European Regional Development Fund [to LL], Grant No. FI17/00294 [to IM-Z], Grant No. PI16/00950 [to JMM], and Grant Nos. CPII16/00048, PI13/01958, and PI16/00889 cofunded by European Regional Development Funds [to CS-M]); the Ontario Mental Health Foundation (Research Training Fellowship [to SHA]); Alberta Innovates Translational Health Chair in Child and Youth Mental Health (to PDA), the Ontario Brain Institute (to PDA); the National Institute of Mental Health (Grant No. K23MH104515 [to JTB], Grant No. K23-MH092397 [to BPB], Grant No. K23MH082176 [to KDF), Grant No. R21MH101441 [to RM], Grant No. R01MH081864 [to JO and JP], and Grant No. R01MH085900 [to JO and JF], Grant No. R21MH093889 [to HBS]); Fundação de Amparo à Pesquisa do Estado de São Paulo (Grant No. 2011/21357–9 [to MCB], Grant No. 2011/21357–9 [to GFB], Grant No. 2011/21357–9 [to MQH], and Grant No. 2011/21357–9 [to ECM]); the Swiss National Science Foundation (Grant No. 320030_130237 [to SB; principal investigator, Susanne Walitza]); the Hartmann Müller Foundation (Grant No. 1460 [to SB]); the David Judah Fund at the Massachusetts General Hospital (to BPB); EU FP7 Project TACTICS (Grant No. 278948 [to JB]); the National Natural Science Foundation of China (Grant No. 81560233 [to YC] and Grant No. 81371340 [to ZW]); the International OCD Foundation (Grant No. K23 MH115206 [to PG]); the Wellcome Sir Henry Dale Fellowship (Grant No. 211155/Z/18/Z [to TUH]); the Jacobs Foundation (to TUH); the Brain and Behavior Research Foundation (2018 NARSAD Young Investigator Grant No. 27023 [to TUH]); the Agency for Medical Research and Development (Grant No. JP18dm0307002 [to YH]); the Michael Smith Foundation for Health Research (to FJ-F); the Federal Ministry of Education and Research of Germany (Grant No. BMBF-01GW0724 [to NK]); the Deutsche Forschungsgemeinschaft (Grant No. KO 3744/7–1 [to KK]); the Helse Vest Health Authority (Grant Nos. 911754 and 911880 [to GK]); the Norwegian Research Council (Grant No. HELSEFORSK 243675 [to GK]); the Marató TV3 Foundation (Grant Nos. 01/2010 and 091710 [to LL]); the Agency for Management of University and Research Grants (Grant No. 2017 SGR 881 [to LL] and 2017 SGR 1247 from the Generalitat de Catalunya [to JMM]); Fundação para a Ciência e a Tecnologia (Grant No. PDE/BDE/113604/2015 from the PhD-iHES Program [to RM], Grant No. PDE/BDE/113601/2015 from the PhD-iHES Program [to PSM]); the Japanese Ministry of Education, Culture, Sports, Science and Technology (Grant-in-Aid for Scientific Research (Grant Nos. 22591262, 25461732, and 16K10253 [to TNakao]); the Government of India Department of Science and Technology (DST INSPIRE Faculty Grant No. -IFA12-LSBM-26 [to JCN] and Grant No. SR/S0/HS/0016/2011 [to YCJR]); the Government of India Department of Biotechnology (Grant No. BT/06/IYBA/2012 [to JCN] and Grant No. BT/PR13334/Med/30/259/2009 [to YCJR]); the New York State Office of Mental Health (to HBS); the Italian Ministry of Health (Grant No. RC13-14-15-16A [to GS]); the National Center for Advancing Translational Sciences (Grant No. UL1TR000067/KL2TR00069 [to ERS]); the Canadian Institutes of Health Research (to SES); the Michael Smith Foundation for Health Research (to SES); the British Columbia Provincial Health Services Authority (to SES); the Netherlands Organization for Scientific Research (Grant No. NWO/ZonMW Vidi 917.15.318 [to GAvW]); the Wellcome-DBT India Alliance (Grant No. 500236/Z/11/Z [to GV]); the Shanghai Key Laboratory of Psychotic Disorders (Grant No. 13dz2260500 [to ZW]).
Databáze: OpenAIRE
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