Secretin, a known gastrointestinal peptide, is widely expressed during mouse embryonic development
| Autor: | Francis K.Y. Siu, Mai Har Sham, Billy K. C. Chow |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Mesenchyme Embryonic Development In situ hybridization Biology digestive system Secretin Mice Internal medicine Genetics medicine Animals Tissue Distribution Intestinal Mucosa Molecular Biology In Situ Hybridization Kidney Embryogenesis Brain Embryo Mammalian Immunohistochemistry Cell biology Intestines medicine.anatomical_structure Endocrinology Ureteric bud Choroid plexus Female hormones hormone substitutes and hormone antagonists Developmental Biology |
| Zdroj: | Gene expression patterns : GEP. 5(3) |
| ISSN: | 1567-133X |
| Popis: | The gastrointestinal functions of the 27-amino acid secretin peptide have been well established. In previous prenatal studies, secretin expression in the rat duodenum was reported after day 17 of gestation while its expression in other organs and its functions in the developing embryos are still unknown. By in situ hybridization and immunohistochemical staining, secretin transcripts and peptides were found to be widely expressed in mouse embryos. Consistent with the idea that secretin is a brain-gut peptide, its expressions are present in several developing brain regions such as cephalic mesenchyme, cerebellar primordium and choroid plexus as well as the epithelial villi lining and inner circular muscle of the developing intestine. Other than these organs, secretin was also detected in the developing heart including the ventricular epicardium and myocardium and certain structures of the developing kidney like ureteric bud, collecting duct and glomerulus. These observations strongly suggest for a functional role of secretin during mouse embryonic development. |
| Databáze: | OpenAIRE |
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