Melanopsin-mediated pupillary responses in bipolar disorder—a cross-sectional pupillometric investigation
| Autor: | Klaus Martiny, Ulla Knorr, Lars Vedel Kessing, Henrik Lund-Andersen, Shakoor Ba-Ali, Ida Hageman, Helle Østergaard Madsen, Steffen Heegaard |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Bipolar disorder Melanopsin Young Mania Rating Scale Retina lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Ophthalmology Pupillary response Medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Circadian rhythm business.industry Research lcsh:QP351-495 Intrinsically photosensitive retinal ganglion cells medicine.disease 030227 psychiatry Psychiatry and Mental health lcsh:Neurophysiology and neuropsychology Mood Pupillometry Mood disorders Pupillary reflex business 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Bipolar Disorders Madsen, H Ø, Ba-Ali, S, Heegaard, S, Hageman, I, Knorr, U, Lund-Andersen, H, Martiny, K & Kessing, L 2021, ' Melanopsin-mediated pupillary responses in bipolar disorder-a cross-sectional pupillometric investigation ', International Journal of Bipolar Disorders, vol. 9, 7 . https://doi.org/10.1186/s40345-020-00211-3 International Journal of Bipolar Disorders, Vol 9, Iss 1, Pp 1-10 (2021) |
| ISSN: | 2194-7511 |
| DOI: | 10.1186/s40345-020-00211-3 |
| Popis: | Background Visible light, predominantly in the blue range, affects mood and circadian rhythm partly by activation of the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs). The light-induced responses of these ganglion cells can be evaluated by pupillometry. The study aimed to assess the blue light induced pupil constriction in patients with bipolar disorder (BD). Methods We investigated the pupillary responses to blue light by chromatic pupillometry in 31 patients with newly diagnosed bipolar disorder, 22 of their unaffected relatives and 35 healthy controls. Mood state was evaluated by interview-based ratings of depressive symptoms (Hamilton Depression Rating Scale) and (hypo-)manic symptoms (Young Mania Rating Scale). Results The ipRGC-mediated pupillary responses did not differ across the three groups, but subgroup analyses showed that patients in remission had reduced ipRGC-mediated responses compared with controls (9%, p = 0.04). Longer illness duration was associated with more pronounced ipRGC-responses (7% increase/10-year illness duration, p = 0.02). Conclusions The ipRGC-mediated pupil response to blue light was reduced in euthymic patients compared with controls and increased with longer disease duration. Longitudinal studies are needed to corroborate these potential associations with illness state and/or progression. |
| Databáze: | OpenAIRE |
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