Radiation‐associated sarcoma after breast cancer in a nationwide population: Increasing risk of angiosarcoma

Autor: Carl Blomqvist, Tom Böhling, Mika Sampo, Laura Tuomikoski, Maija Tarkkanen, Samuli H. Salminen
Přispěvatelé: HUSLAB, Clinicum, Department of Pathology, Medicum, Doctoral Programme in Clinical Research, Tom Böhling / Principal Investigator, Rectors, University of Helsinki, Department of Oncology, HUS Comprehensive Cancer Center
Rok vydání: 2018
Předmět:
Oncology
Cancer Research
Neoplasms
Radiation-Induced
sarcoma
medicine.medical_treatment
THERAPY
SOFT-TISSUE SARCOMAS
hemangiosarcoma
0302 clinical medicine
Risk Factors
breast neoplasms
Public Health Surveillance
Angiosarcoma
030212 general & internal medicine
Finland
Mastectomy
education.field_of_study
Neoplasms
Second Primary
CHEMOTHERAPY
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Combined Modality Therapy
3. Good health
Treatment Outcome
030220 oncology & carcinogenesis
SURVIVAL
Female
Sarcoma
BONE
medicine.medical_specialty
CARCINOMA
3122 Cancers
Population
Risk Assessment
lcsh:RC254-282
03 medical and health sciences
Breast cancer
Internal medicine
medicine
Carcinoma
Humans
Radiology
Nuclear Medicine and imaging
INSTITUTION
education
radiotherapy
business.industry
registries
medicine.disease
Cancer registry
Radiation therapy
Hemangiosarcoma
business
Zdroj: Cancer Medicine, Vol 7, Iss 9, Pp 4825-4835 (2018)
ISSN: 2045-7634
DOI: 10.1002/cam4.1698
Popis: Radiation-associated sarcoma (RAS) is a rare complication of radiation therapy (RT) to breast cancer (BC). This study explored RAS after RT to BC in a nationwide population-based material. The Finnish Cancer Registry was queried for patients with BC treated during 1953-2014 who were later diagnosed with a secondary sarcoma in 1953-2014. Registry data, patient files, and sarcoma specimens were analyzed to confirm diagnosis and location of RAS at or close to the RT target volume. A total of 132 512 patients were diagnosed with invasive BC during the study period. A subsequent sarcoma was diagnosed in 355 patients. After exclusion, 96 RAS were identified. Angiosarcoma (AS) was the most prevalent histology in 50 (52%) of 96 patients. However, the first radiation-associated AS was diagnosed in a patient treated for BC with breast-conserving surgery in 1984, and thereafter, the proportion of AS continuously increased. The 5-year sarcoma-specific survival was 75.1% for RAS treated with a curative intent. The distribution of histologic subtypes of RAS has changed during the 60 years of this registry study. The first radiation-associated AS was diagnosed in 1989, and presently, AS is the most common histologic subtype of RAS. It is possible that changes in BC treatment strategies are influencing the characteristics of RAS.
Databáze: OpenAIRE
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