Effect of Immunization of Mothers on Cytomegalovirus Infection in Suckling Mice
| Autor: | Sandra L. Prokay, Donald N Medearis |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Cytomegalovirus
Weanling Spleen Antibodies Viral General Biochemistry Genetics and Molecular Biology Virus Mice Pregnancy Animals Medicine Antigens Viral Maternal-Fetal Exchange Brain Diseases biology Salivary gland business.industry Immunization Passive Milk medicine.anatomical_structure Animals Newborn Immunization In utero Cytomegalovirus Infections Immunology biology.protein Female Antibody business Breast feeding |
| Zdroj: | Experimental Biology and Medicine. 157:523-527 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-157-40089 |
| Popis: | SummaryFemale weanling mice were immunized with suspensions of MCMV infected salivary glands, then mated. Protection was conferred to their young by breast feeding, and to a lesser extent it was acquired in utero. Protection was manifested by a reduction in mortality, and by a reduction in the quantity of virus recovered from brain, liver, spleen, and salivary gland after challenge with 30 LD50. Neutralization antibody (plaque reducing activity) was present in serum of immunized females and in the plasma of sucklings born of and nursed by them, or those only nursed by them. It was not present in unimmunized females or in sucklings born of but not nursed by immunized females. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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