RRM Prediction of Erythrocyte Band3 Protein as Alternative Receptor for SARS-CoV-2 Virus

Autor: Ivan Loncarevic, Drasko Cosic, Irena Cosic
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
030303 biophysics
coronavirus
ACE2
resonant recognition model
Biology
medicine.disease_cause
lcsh:Technology
Virus
protein–receptor interaction
lcsh:Chemistry
03 medical and health sciences
medicine
General Materials Science
Respiratory system
Receptor
Instrumentation
lcsh:QH301-705.5
030304 developmental biology
Coronavirus
Fluid Flow and Transfer Processes
chemistry.chemical_classification
0303 health sciences
SARS-CoV-2
lcsh:T
Process Chemistry and Technology
General Engineering
COVID-19
respiratory system
Virology
lcsh:QC1-999
Computer Science Applications
respiratory tract diseases
Red blood cell
medicine.anatomical_structure
Enzyme
chemistry
lcsh:Biology (General)
lcsh:QD1-999
lcsh:TA1-2040
Breathing
blood cells
lcsh:Engineering (General). Civil engineering (General)
lcsh:Physics
Zdroj: Applied Sciences, Vol 10, Iss 4053, p 4053 (2020)
Applied Sciences
Volume 10
Issue 11
ISSN: 2076-3417
Popis: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new coronavirus causing a worldwide pandemic. It is infecting respiratory organs and, in more severe cases, the lungs, where it is infecting the human cells through the angiotensin-converting enzyme 2 (ACE2) receptor. In severe cases, it is characterized not only by difficulties in breathing through infected lungs, but also with disproportionally and, thus far, unexplained low levels of oxygen in the blood. Here, we propose that, besides the infection of respiratory organs through ACE2 receptors, there is an additional infection in the red blood cells (erythrocytes). There could be a possible for SARS-CoV-2 to pass through the alveoli membrane in the lungs and infect the red blood cells through another receptor. Using our own biophysical model, the Resonant Recognition Model, we propose that the red blood cell (RBC) Band3 protein on the surface of red blood cells is a possible entry point for the SARS-CoV-2 virus into red blood cells.
Databáze: OpenAIRE
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