Bronchial hyperresponsiveness in subjects with gastroesophageal reflux
| Autor: | F. Purello D’Ambrosio, S. Gulli, R. De Pasquale, Gianfilippo Bagnato, O. Giacobbe |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Prevalence medicine Humans Methacholine Chloride Asthma Bronchus Esophageal disease business.industry fungi Respiratory disease Reflux Middle Aged respiratory system medicine.disease respiratory tract diseases medicine.anatomical_structure Bronchial hyperresponsiveness Case-Control Studies Anesthesia Gastroesophageal Reflux Female Methacholine Bronchial Hyperreactivity business Airway medicine.drug |
| Popis: | Background: The relationship between gastroesophageal reflux (GER) and asthma has been widely studied in the last years. GER may interfere with airway reactivity and aggravate or even induce asthma. Objective: To assess the prevalence of bronchial hyperresponsiveness (BHR) in patients with GER disease with a view to judging the potential influence of GER on BHR. Methods: 30 patients with GER disease and no clinical evidence of asthma and 30 normal subjects underwent a methacholine bronchial challenge. The methacholine concentration that caused a 20% fall in the FEV1 (PC20) was used to assess bronchial responsiveness. Results: In the GER group 11 subjects of the 30 studied showed a PC20 methacholine equal to or less than 8 mg/ml while in the control group only 2 subjects had a PC20 methacholine equal to or less than 8 mg/ml (p < 0.01; ANOVA test). Conclusions: Subjects with GER had a greater increase in airway reactivity when inhaling methacholine compared to disease-free normal subjects. |
| Databáze: | OpenAIRE |
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