Two-Step Route to Diverse N-Functionalized Peptidomimetic-like Isatins through an Oxidation/Intramolecular Oxidative-Amidation Cascade of Ugi Azide and Ugi Three-Component Reaction Products

Autor:	Christopher Foley, Christopher Hulme, Arthur Y. Shaw
Rok vydání:	2016
Předmět:	010405 organic chemistry Peptidomimetic Organic Chemistry Two step Oxidative phosphorylation 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound chemistry Intramolecular force Organic chemistry Azide Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 18:4904-4907
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.6b02383
Popis:	Two-step methodology described herein showcases the first example of an oxidation/oxidative amidation cyclization cascade of MCR products toward diverse N-functionalized isatins. Products of both the Ugi 3CR and the Ugi azide reactions are oxidatively cyclized through a postcondensation process utilizing selenium dioxide. This methodology was found to be applicable for the generation of bis-peptidomimetic-like isatins containing multiple points of diversification.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d654638c71a00171b7f1707be4bf0ce https://doi.org/10.1021/acs.orglett.6b02383 Zobrazit plný text záznamu