Levels of dechloranes and polybrominated diphenyl ethers (PBDEs) in human serum from France
| Autor: | Jean-François Viel, Georges Scholl, Catherine Brasseur, Jean-François Focant, Li Shen, Edwin De Pauw, Eric J. Reiner, Catherine Pirard |
|---|---|
| Přispěvatelé: | Center for Analytical Research and Technology (CART), Université de Liège, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Ontario Ministry of the Environment, The DP standard solutions and the GC column were kindly provided by Cambridge Isotope Laboratories (CIL, Andover, MS, USA) and Phenomenex (Utrecht, The Netherlands), respectively., Lecoupe-Grainville, Marie, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male PBDEs Biology MESH: Hydrocarbons Chlorinated Blood serum Flame retardants chemistry.chemical_compound Polybrominated diphenyl ethers Animal science MESH: Aged 80 and over Halogenated Diphenyl Ethers Hydrocarbons Chlorinated Humans No production lcsh:Environmental sciences General Environmental Science Aged Aged 80 and over lcsh:GE1-350 MESH: Aged [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology MESH: Middle Aged MESH: Humans Dechloranes MESH: Halogenated Diphenyl Ethers Organochlorine pesticide MESH: Adult Dechlorane plus Middle Aged Serum samples MESH: Male 3. Good health Human biomonitoring MESH: France chemistry MESH: Environmental Pollutants Human exposure Bioaccumulation Environmental chemistry Environmental Pollutants Female France MESH: Environmental Monitoring MESH: Female [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology Environmental Monitoring |
| Zdroj: | Environment International Environment International, Elsevier, 2014, 65, pp.33-40. ⟨10.1016/j.envint.2013.12.014⟩ Environment International, Vol 65, Iss, Pp 33-40 (2014) Environment International, 2014, 65, pp.33-40. ⟨10.1016/j.envint.2013.12.014⟩ |
| ISSN: | 0160-4120 |
| Popis: | Human exposure to dechloranes has been evaluated in Western Europe (France) with the analysis of Dechlorane Plus (DP), Dechloranes (Dec) 602, 603 and 604, Chlordene Plus (CP) and Mirex in 48 serum samples collected between 2003 and 2005. While no production source has been identified in Europe until now, detection frequencies for all investigated dechloranes were high, except for Dec 604 which was below detection limit for all samples. The mean DP concentration was 1.40 ± 1.40 ng/g lipid weight (lw), lower than levels reported in serum from Chinese population, but higher than levels reported in Canadian human milk. To the best of our knowledge, this is the first time that ∑5dechlorane levels are reported for human serum. A specific pattern of contamination was found (Dec 603 > DP > Mirex > Dec 602 > CP) compared to other biota samples that have been analyzed from Europe, with Dec 603 as the most abundant dechlorane (mean level: 2.61 ± 2.63 ng/g lw). Dec 603 and CP levels were correlated with age and with levels of some bioaccumulative organochlorine pesticides (OCPs). These results indicate that bioaccumulation properties should be further investigated and taken in consideration when assessing human exposure to dechloranes. For comparison purposes, polybrominated diphenyl ether (PBDE) levels were also measured for BDE-47, -99, -100, -153 and -154 in the serum samples. As expected, BDE-47 and BDE-153 were the major congeners with mean levels of 2.06 ± 1.80 ng/g lw and 1.39 ± 0.97 ng/g lw, respectively. The mean ∑5PBDE levels (4.32 ± 2.99 ng/g lw) were in the range typical of Western Europe levels, but lower than the mean ∑5dechlorane levels (6.24 ± 4.16 ng/g lw). These results indicate that the attention to dechloranes should be continued if research indicates toxicological concerns. Keywords: Dechloranes, Human biomonitoring, Flame retardants, Blood serum, PBDEs |
| Databáze: | OpenAIRE |
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