Evaluation of the renal excretion characteristics of technetium-99m mercaptoacetylglycyl-D-alanylglycine in healthy volunteers
| Autor: | Cleynhen Bj, De Roo Mj, Alfons Verbruggen, Guy Bormans |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Urinary system Renal function chemistry.chemical_element Kidney Technetium High-performance liquid chromatography Technetium Tc 99m Mertiatide Internal medicine biology.animal medicine Humans Radiology Nuclear Medicine and imaging biology Organotechnetium Compounds General Medicine Endocrinology medicine.anatomical_structure chemistry Renal physiology Oligopeptides Radioisotope Renography Technetium-99m Baboon |
| Zdroj: | European Journal of Nuclear Medicine. 19:271-277 |
| ISSN: | 1619-7089 0340-6997 |
| DOI: | 10.1007/bf00175141 |
| Popis: | During a study of C-methyl derivatives of technetium-99m mercaptoacetyltriglycine (99mTc-MAG3) it was found that the isomer of 99mTc-mercaptoacetylgly-cyl-D-alanylglycine (99m-TC-MAGAG-DA) is superior to 99mTc-MAG3 with regard to its renal excretion characteristics in both mice and the baboon. We have now compared the renal handling of 99mTc-MAGAG-DA and 99mTc-MAG3 in 6 healthy volunteers in a paired study. Renograms of 99mTc-MAGAG-DA show a shorter time to renal maximum and a lower residual renal activity at 30 min post-injection (p.i.). The urinary excretion of 99mTc-MAGAG-DA is higher at both 30 and 60 min p.i. The plasma concentration of 99mTc-MAGAG-DA is lower than that of 99mTc-MAG3 at each moment up to 60 min p.i., and the plasma clearance is accordingly higher. It is concluded that 99mTc-MAGAG-DA is excreted more efficiently than 99mTc-MAG3, but the preparation of 99mTc-MAGAG-DA requires a HPLC purification step, and this limits its practical clinical usefulness. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink