Direct action of d-lysergic acid diethylamide on dispersed mucosal cells from guinea pig stomach
| Autor: | Shmuel Batzri, Jean Dyer |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Pharmacology
Histamine binding Chemistry Guinea pig stomach Histamine antagonists Guinea Pigs D-lysergic acid diethylamide Brain tissue In Vitro Techniques Biochemistry Partial agonist Guinea pig Kinetics Lysergic Acid Diethylamide chemistry.chemical_compound Gastric Mucosa Cyclic AMP Animals Aminopyrine Histamine |
| Zdroj: | Biochemical Pharmacology. 31:2676-2679 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/0006-2952(82)90718-3 |
| Popis: | In dispersed mucosal cells from guinea pig stomach, D-lysergic acid diethylamide (LSD) was a partial agonist with respect to histamine. LSD, like histamine, inhibited [3H]histamine binding and increased both cellular cyclic AMP and [14C]aminopyrine uptake by interacting with histamine H2-receptors on parietal cells. These processes were blocked by both histamine H1- and H2-antagonists and, thus, provide evidence that histamine H2-receptors on guinea pig parietal cells resemble those in brain tissue in that they interact with LSD as well as with both classes of histamine antagonists. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|