Expression of Syndecan-1 in Chronic Liver Diseases: Correlation With Hepatic Fibrosis
| Autor: | Antonia Charchanti, Anna Goussia, N.J. Agnantis, Agapi Kataki, Efthymios Koniaris, Georgios K. Glantzounis, Panagiotis Kanavaros |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Liver Cirrhosis Cancer Research Pathology medicine.medical_specialty Membrane Glycoproteins business.industry medicine.disease Heparan Sulfate Proteoglycans Immunohistochemistry General Biochemistry Genetics and Molecular Biology Syndecan 1 carbohydrates (lipids) Tissue sections Fibrosis Liver tissue Medicine Humans Syndecan-1 Stage (cooking) business Hepatic fibrosis Research Article |
| Zdroj: | In Vivo |
| Popis: | Background/Aim: The mechanisms underlying the contribution of the heparan sulfate proteoglycan syndecan-1 to liver tissue injury and to crucial biological processes, such as fibrogenesis, remain to be elucidated. Therefore, we investigated the immunohistochemical expression of syndecan-1 in chronic liver diseases (CLDs) and its probable role in hepatic fibrosis. Materials and Methods: Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections of biopsy material obtained from 128 patients diagnosed with CLDs. The correlation between syndecan-1 expression and the stage of fibrosis was investigated. Results: According to the severity of fibrosis, cases were categorized into three groups: early fibrosis; intermediate fibrosis; advanced fibrosis. Syndecan-1 expression was significantly enhanced in advanced fibrosis compared to early (p |
| Databáze: | OpenAIRE |
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