With low ovarian reserve, Highly Individualized Egg Retrieval (HIER) improves IVF results by avoiding premature luteinization

Autor: Lin Zhang, Qi Wang, Vitaly A. Kushnir, Yan-Guang Wu, David F. Albertini, Norbert Gleicher, David H. Barad, Sarah K. Darmon
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Adult
endocrine system
Pregnancy Rate
media_common.quotation_subject
Oocyte Retrieval
Fertilization in Vitro
Primary Ovarian Insufficiency
lcsh:Gynecology and obstetrics
Human chorionic gonadotropin
Andrology
03 medical and health sciences
Follicle
0302 clinical medicine
Ovarian Follicle
Advanced female age
Pregnancy
Progesterone receptor
Medicine
Humans
Ovarian reserve
Ovarian Reserve
Ovulation
Menstrual Cycle
lcsh:RG1-991
media_common
030219 obstetrics & reproductive medicine
Granulosa Cells
business.industry
Occult primary ovarian insufficiency (oPOI)
Research
luteinizing hormone/choriogonadotropin receptor
Obstetrics and Gynecology
Premature luteinization
Middle Aged
medicine.disease
In vitro fertilization (IVF)
Luteinization
Pregnancy rates
030104 developmental biology
Premature ovarian aging (POA)
Oncology
Female
business
Follicle-stimulating hormone receptor
Zdroj: Journal of Ovarian Research, Vol 11, Iss 1, Pp 1-7 (2018)
Journal of Ovarian Research
ISSN: 1757-2215
DOI: 10.1186/s13048-018-0398-8
Popis: Background Highly Individualized Egg Retrieval (HIER), defined as age-specific early oocyte retrieval (ER), has been demonstrated to avoid premature luteinization in women ≥43. We here investigated whether HIER also applies to younger women with premature ovarian aging (POA), and what best lead follicle size should be for administration of ovulation-triggers. Methods Fifty-six women ≥43, and 37 POA patients underwent IVF cycles. Granulosa cells (GCs) were isolated, cultures were established, RNA was extracted and real-time PCR analyses performed, with gene expressions at mRNA level investigated for FSH receptor (FSHR), luteinizing hormone receptor (LHCPR), P450 aromatase (CYP19a1) and progesterone receptor (PGR). POA was defined by age
Databáze: OpenAIRE
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