Biological Safety Evaluation and Surface Modification of Biocompatible Ti–15Zr–4Nb Alloy
| Autor: | Shin-ichi Katsuda, Yoshimitsu Okazaki |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
medicine.medical_treatment Alloy engineering.material lcsh:Technology biological safety evaluation Article Rod Alloy surface grit blasting osteocompatibility Surface roughness medicine General Materials Science Composite material lcsh:Microscopy Dental implant lcsh:QC120-168.85 accelerated extraction Ti–15Zr–4Nb alloy lcsh:QH201-278.5 lcsh:T ISO 10993 series technology industry and agriculture morphometrical parameters equipment and supplies Biocompatible material Biological safety lcsh:TA1-2040 maximum pullout load engineering Surface modification lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering lcsh:Engineering (General). Civil engineering (General) lcsh:TK1-9971 |
| Zdroj: | Materials Volume 14 Issue 4 Materials, Vol 14, Iss 731, p 731 (2021) |
| ISSN: | 1996-1944 |
| Popis: | We performed biological safety evaluation tests of three Ti–Zr alloys under accelerated extraction condition. We also conducted histopathological analysis of long-term implantation of pure V, Al, Ni, Zr, Nb, and Ta metals as well as Ni–Ti and high-V-containing Ti–15V–3Al–3Sn alloys in rats. The effect of the dental implant (screw) shape on morphometrical parameters was investigated using rabbits. Moreover, we examined the maximum pullout properties of grit-blasted Ti–Zr alloys after their implantation in rabbits. The biological safety evaluation tests of three Ti–Zr alloys (Ti–15Zr–4Nb, Ti–15Zr–4Nb–1Ta, and Ti–15Zr–4Nb–4Ta) showed no adverse (negative) effects of either normal or accelerated extraction. No bone was formed around the pure V and Ni implants. The Al, Zr, Nb, and Ni–Ti implants were surrounded by new bone. The new bone formed around Ti–Ni and high-V-containing Ti alloys tended to be thinner than that formed around Ti–Zr and Ti–6Al–4V alloys. The rate of bone formation on the threaded portion in the Ti–15Zr–4Nb–4Ta dental implant was the same as that on a smooth surface. The maximum pullout loads of the grit- and shot-blasted Ti–Zr alloys increased linearly with implantation period in rabbits. The pullout load of grit-blasted Ti–Zr alloy rods was higher than that of shot-blasted ones. The surface roughness (Ra) and area ratio of residual Al2O3 particles of the Ti–15Zr–4Nb alloy surface grit-blasted with Al2O3 particles were the same as those of the grit-blasted Alloclassic stem surface. It was clarified that the grit-blasted Ti–15Zr–4Nb alloy could be used for artificial hip joint stems. |
| Databáze: | OpenAIRE |
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