Autor: |
Xia, Ya-Nan, Zu, He, Guo, Haoxiang, Jiang, Tianyan, Yang, Siqi, Yu, Huan, Zhang, Shaodian, Ding, Heng, Li, Xiaoyu, Wang, Yangyun, Wang, Yong, Zhang, Leshuai W. |
Rok vydání: |
2022 |
DOI: |
10.6084/m9.figshare.19589253 |
Popis: |
Additional file 1: Figure S1. Physicochemical characterization of BSA@Cu2−xS NPs regarding to their photothermal and photoacoustic effects along with size and photothermal stability. Figure S2. The gross findings and organ coefficient analysis by LNPs and SNPs. Figure S3. Hematological parameters of the rats in control and dosing groups (2, 5 and 8 mg/kg for 14 days) administered with LNPs and SNPs at the end of dosing period. Figure S4. The serum CREA and UA levels as indicators for kidney injury in control rats and dosing groups at Day 1, 3, 7 and 14 when consecutively treated with LNPs and SNPs for 14 days. Figure S5. H&E staining of heart, liver, spleen, lung, and kidney for the rats in control and dosing groups administered with LNPs and SNPs. Figure S6. The mRNA level of IL-1β, PPAR-α, PPAR-γ, NTCP, BSEP, MRP2, MRP3, MRP4, ATP7B and Ceruloplasmin (CP) in the liver of the rats dosed with 8 mg/kg LNPs and SNPs after the dosing period and recovery period. Table S1. Primer pairs used for real-time quantitative PCR. Table S2. Pharmacokinetic parameters of LNPs and SNPs by a single-dose intravenous injection in the SD rats. Table S3. The differentially expressed genes (DEGs) between control and L- or S-BSA@Cu2−xS NPs dosing groups (L8 and S8). |
Databáze: |
OpenAIRE |
Externí odkaz: |
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