Long-term toxicity studies of erythrosine. I. Effects in rats and dogs
| Autor: | J.B. Brouwer, O.G. Fitzhugh, R.E. Zwickey, W.H. Hansen |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
medicine.medical_specialty Injections Subcutaneous Administration Oral Physiology Weanling Spleen Distension Toxicology Beagle Lethal Dose 50 chemistry.chemical_compound Dogs medicine Animals Ingestion Cecum Nephritis business.industry Incidence (epidemiology) Body Weight Histology Organ Size Fluoresceins Erythrosine Rats Surgery medicine.anatomical_structure chemistry Female Food Additives business Iodine |
| Zdroj: | Food and Cosmetics Toxicology. 11:527-534 |
| ISSN: | 0015-6264 |
| DOI: | 10.1016/s0015-6264(73)80323-2 |
| Popis: | Groups of 12 male and 12 female weanling Osborne-Mendel rats were fed diets containing erythrosine (FD & C Red No. 3) at levels of 0, 0·5, 1·0, 2·0 or 5·0% for 2 yr. Growth depression was observed in the rats given the 5·0% level. Spleen weights, expressed as organ-to-body weight ratios, were decreased in the male rats given the 0·5, 2·0 and 5·0% dose levels and in female rats given the 5·0% dose level. Slight caecal distension occurred in rats given erythrosine at 1·0 % and the condition increased with increasing dose levels. The histology of the distended caeca was normal. Chronic nephritis was approximately doubled in incidence in the 0·5 % group compared with that in the control group, but this was probably due to chance variation. Weekly sc injections of erythrosine (approximately 12 mg/rat) were given to a group of 18 rats for 2 yr. Injection-site ulcerations were produced but no tumours were observed. In an acute oral toxicity study in rats, the LD50 of erythrosine was found to be 1840 mg/kg. In another long-term study, erythrosine was fed at dietary levels of 0, 0·5, 1·0 or 2·0% to groups of three male and three female beagle dogs. All dogs survived the 2-yr period and no effects attributable to the ingestion of erythrosine were observed. |
| Databáze: | OpenAIRE |
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