Respiratory infections in cystic fibrosis patients caused by virus, chlamydia and mycoplasma--possible synergism with Pseudomonas aeruginosa
Autor: | K. Lind, N. T. Petersen, Niels Høiby, E. W. Flensborg, B. Bruun, C. H. Mordhorst |
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Rok vydání: | 1981 |
Předmět: |
Adult
Male Mycoplasma pneumoniae Adolescent Cystic Fibrosis medicine.disease_cause Cystic fibrosis Virus Microbiology medicine Humans Chlamydia Child Respiratory Tract Infections Pseudomonas aeruginosa business.industry Respiratory disease Infant General Medicine Mycoplasma medicine.disease Antibodies Bacterial Child Preschool Pediatrics Perinatology and Child Health Immunology Viruses Sputum Female medicine.symptom business |
Zdroj: | Acta paediatrica Scandinavica. 70(5) |
ISSN: | 0001-656X |
Popis: | 116 cystic fibrosis patients were observed, by monthly examinations over an eight-month period, to investigate the importance of non-bacterial respiratory infections (NBI) in exacerbations of the respiratory disease. Sputum was examined for bacteria, and serum investigated for antibody response against virus, mycoplasma and chlamydia and for antibodies against Pseudomonas aeruginosa. During this period each patient had, on an average, 2.9 exacerbations of which 76% were associated with bacteria, most frequently P. aeruginosa (51%), and 20% with NBI, although bacteria were also present in most of these cases. No etiology was established in 18% of the exacerbations. The NBI were caused by respiratory syncytial virus (RSV) (9%), parainfluenza virus (5%), influenza virus (3.6%), adenovirus (2.4%), mycoplasma (0.6%) and chlamydia (0.6%). The incidence of exacerbations was higher in patients with chronic P. aeruginosa infections. RSV infections were more common in patients who developed chronic P. aeruginosa infection during the study period, and RSV infections were frequently associated with a rise of P. aeruginosa antibodies in patients who harboured these bacteria. The important role of NBI as mediators of onset of chronic P. aeruginosa infections in cystic fibrosis patients is suggested. |
Databáze: | OpenAIRE |
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