An acute intratracheal selenium study: Immediate effects on respiration in guinea pigs
| Autor: | Rosonald R Bell, Vani K Nonavinakere, Annabeth S Proctor, Johnnie L. Early, Zandra Y Mallory |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Respiratory rate Guinea Pigs Toxicology Pulmonary function testing Airway resistance Selenium Oxides Internal medicine Respiration Intubation Intratracheal medicine Animals Selenium Compounds Selenomethionine Lung Tidal volume business.industry Respiratory disease Intrapleural pressure General Medicine medicine.disease Respiratory Function Tests Endocrinology medicine.anatomical_structure Anesthesia Respiratory Mechanics Pulmonary Ventilation business |
| Zdroj: | Toxicology Letters. 104:231-237 |
| ISSN: | 0378-4274 |
| DOI: | 10.1016/s0378-4274(98)00374-9 |
| Popis: | Pulmonary function was assessed in non-sensitized male guinea pigs (206–445 g) before and after intratracheal (ITr) treatment with saline or selenium (Se, 0.06 mg/100 g body weight) as selenium dioxide (SeO2) or seleno-l-methionine (SeM). Pulmonary functional parameters such as the respiratory rate (f), tidal volume (TV), dynamic lung compliance (Cdynl) and lung resistance (Rl) were determined using the respiratory flow (F) signal and the transpulmonary signal obtained via the intrapleural pressure (P) from the animal. Although, pulmonary dysfunction was observable with exposure to two different Se compounds, the SeO2-induced changes in f and Rl were significant (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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