Protection from infectious bursal disease virus (IBDV)-induced immunosuppression by immunization with a fowlpox recombinant containing IBDV-VP2
| Autor: | B. J. G. Baaten, T D M Sturman, C. Butter, T. F. Davison |
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| Rok vydání: | 2003 |
| Předmět: |
Fowlpox
animal structures Biology Antibodies Viral Infectious bursal disease virus Virus Infectious bursal disease Random Allocation Food Animals medicine Animals Poultry Diseases Viral Structural Proteins Salmonella Infections Animal Vaccines Synthetic Fowlpox virus General Immunology and Microbiology Viral Vaccine Viral Vaccines Salmonella vaccine Birnaviridae Infections Vaccine efficacy medicine.disease Virology Specific Pathogen-Free Organisms Bacterial vaccine Immunoglobulin M Salmonella enteritidis Immunization Bacterial Vaccines Immunology Animal Science and Zoology Chickens |
| Zdroj: | Avian Pathology. 32:597-604 |
| ISSN: | 1465-3338 0307-9457 |
| Popis: | Immunosuppression resulting from infectious bursal disease virus (IBDV) infection has critical health and welfare implications for birds, yet it is incompletely understood and largely overlooked as a measure of vaccine efficacy. The ability of a fowlpoxvirus recombinant (fpIBD1) containing the VP2 protein of IBDV to protect against IBDV-induced immunosuppression was investigated by measuring the convalescent chicken's ability to mount antibody responses to IBDV infection, and to inactivated IBDV and salmonella vaccines. An immunoglobulin (Ig)M response, but no IgG response, occurred after IBDV infection. Uninfected chickens produced a sustained IgM response and some IgG response to inactivated IBDV vaccine, while in previously infected birds only a transient IgM response was detected. A moderate suppression of the response to a commercial salmonella vaccine was evident after IBDV infection, which was largely prevented by immunization with fpIBD1. These results indicate that measurement of immunosuppression could be a useful strategy for assessing the efficacy of vaccines to protect against the consequences of IBDV infection. |
| Databáze: | OpenAIRE |
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