Physical-Chemical Characterization and Polymorphism Determination of Two Nimodipine Samples Deriving from Distinct Laboratories
| Autor: | Hellen Karine Stulzer, Jivaldo do Rosário Matos, Marcos Antonio Segatto Silva, Patrik Oening Rodrigues, Teófilo Mazon Cardoso |
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| Rok vydání: | 2005 |
| Předmět: |
Quality Control
Scanning electron microscope Analytical chemistry Pharmaceutical Science Mineralogy Raw material Crystallinity Drug Stability X-Ray Diffraction Drug Discovery Microscopy Transition Temperature Thermal analysis Chromatography High Pressure Liquid Pharmacology Calorimetry Differential Scanning Chemistry Organic Chemistry Calcium Channel Blockers Thermogravimetry X-ray crystallography Microscopy Electron Scanning Nimodipine Crystallization Powder Diffraction Powder diffraction |
| Zdroj: | Drug Development and Industrial Pharmacy. 31:631-637 |
| ISSN: | 1520-5762 0363-9045 |
| DOI: | 10.1080/03639040500216212 |
| Popis: | Knowing the characteristics of raw materials in pharmaceutical practice is both important and useful. Firstly, evaluating the physical-chemical properties of the substances that will be used must be the primary step for quality control in the pharmacy industry. This work aims at analyzing the physical-chemical characteristics of two nimodipine samples I and II derived from distinct laboratories through thermal analysis (DSC and TG/DTG), HPLC, crystallography, and microscopy. Thermal analysis showed that sample II was more unstable than I. Morphological differences concerning shape, size, and crystallinity of particles were visualized by scanning electron microscopy (SEM) and X-ray powder diffraction. To sum up, the techniques used in this study can be said to have been efficient in the characterization and evaluation of quality control of the raw material. |
| Databáze: | OpenAIRE |
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