Potential Nonresponse Bias in a Clinical Examination After Initial Screening Using Iron Phenotyping and HFE Genotyping in the Hemochromatosis and Iron Overload Screening Study
| Autor: | Leah Passmore, Helen Harrison, James C. Barton, David M. Reboussin, Charles A. Rivers, Margaret Fadojutimi-Akinsiku, Sharmin Diaz, Mark Speechley, Emily L. Harris, Lari Wenzel |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Iron Overload Genotype Iron Physical examination Primary care Bias medicine Humans Mass Screening Non-response bias Genetic Testing Hemochromatosis Protein Intensive care medicine Genotyping Genetics (clinical) Hemochromatosis Screening study medicine.diagnostic_test business.industry Histocompatibility Antigens Class I Membrane Proteins Original Articles General Medicine Middle Aged medicine.disease Phenotype Immunology Female business |
| Zdroj: | Genetic Testing and Molecular Biomarkers. 13:721-728 |
| ISSN: | 1945-0257 1945-0265 |
| DOI: | 10.1089/gtmb.2009.0003 |
| Popis: | Background: Little is known about the factors affecting participation in clinical assessments after HEmochromatosis and IRon Overload Screening. Methods: Initial screening of 101,168 primary care patients in the HEmochromatosis and IRon Overload Screening study was performed using serum iron measures and hemochromatosis gene (HFE) genotyping. Using iron phenotypes and HFE genotypes, we identified 2256 cases and 1232 controls eligible to participate in a clinical examination. To assess the potential for nonresponse bias, we compared the sociodemographic, health status, and attitudinal characteristics of participants and nonparticipants using adjusted odds ratios (ORs) and 95% confidence interval (CI). Results: Overall participation was 74% in cases and 52% in controls; in both groups, participation was highest at a health maintenance organization and lowest among those under 45 years of age (cases: OR = 0.68; 95% CI 0.53, 0.87; controls: OR = 0.59; 95% CI 0.44, 0.78). In controls only, participation was also lower among those over 65 years of age than the reference group aged 46–64 (OR = 0.64; 95% CI 0.47, 0.88). Among cases, participation was higher in HFE C282Y homozygotes (OR = 3.98; 95% CI 2.60, 6.09), H63D homozygotes (OR = 2.79; 95% CI 1.23, 6.32), and C282Y/H63D compound heterozygotes (OR = 1.82; 95% CI 1.03, 3.22) than in other genotypes, and lower among non-Caucasians and those who preferred a non-English language than in Caucasians and those who preferred English (p |
| Databáze: | OpenAIRE |
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