CCR1 Chemokine Receptor Antagonist
| Autor: | Akira Naya, Toshihiko Saeki |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Inflammation
Pharmacology CCR1 Chemokine Molecular Structure biology Chemokine receptor CCR5 business.industry Anti-Inflammatory Agents Non-Steroidal Receptors CCR1 CCL3 CCL5 Chemokine Receptor Antagonist Structure-Activity Relationship Drug Discovery Immunology biology.protein Animals Humans Medicine Receptors Chemokine Receptor business G protein-coupled receptor |
| Zdroj: | Current Pharmaceutical Design. 9:1201-1208 |
| ISSN: | 1381-6128 |
| Popis: | The selective accumulation and activation of leukocytes in inflamed tissues contributes to the pathogenesis of inflammatory and autoimmune diseases such as infection, rheumatoid arthritis, allergic asthma, atopic dermatitis, and multiple sclerosis. A substantial body of reports suggests that chemokines and their receptors, which belong to a family of seven transmembrane G-protein coupled receptors (GPCR), may be involved in the selective accumulation and activation of leukocytes in inflamed tissues, and in the pathogenesis of inflammatory and autoimmune diseases. One such receptor is CCR1 which is a receptor for CC chemokines, such as CCL5 (RANTES) and CCL3 (MIP-1alpha). The involvement of CCR1 in immunological diseases now is documented in several preclinical studies with CCR1 deficient mice, anti-CCR1 antibodies and CCR1 antagonists, suggesting that CCR1 may be an attractive therapeutic target for a variety of diseases. Publications and patents describing CCR1 antagonists and their pharmacological effects have recently been disclosed. This review highlights the biology and pathophysiology of CCR1, and some of its currently reported antagonists. Additionally, our approach to CCR1 drug discovery is summarized. |
| Databáze: | OpenAIRE |
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