Use of platelet-rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw
| Autor: | Sacramento Bocanegra-Pérez, José María Castellano-Navarro, Mario Vicente-Barrero, J. Rodríguez-Millares, Milan Knezevic, D. Pérez-Plasencia, E. Rodríguez-Bocanegra, A. Ramos-Macías |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Necrosis medicine.medical_treatment Bone healing Asymptomatic Medicine Humans Aged Debridement business.industry Platelet-Rich Plasma Bisphosphonate Middle Aged medicine.disease Curettage Surgery Otorhinolaryngology Platelet-rich plasma Bisphosphonate-Associated Osteonecrosis of the Jaw Female Oral Surgery medicine.symptom business Osteonecrosis of the jaw |
| Zdroj: | International journal of oral and maxillofacial surgery. 41(11) |
| ISSN: | 1399-0020 |
| Popis: | Platelet-rich plasma is a concentrate of growth factors and osteoconductive proteins, which can play a major role in bone biology by accelerating and enhancing bone repair and regeneration. This paper describes the results of using platelet-rich plasma in the management of bisphosphonate-associated necrosis of the jaw. Eight patients with a diagnosis of bisphosphonate-associated necrosis of the jaw were surgically treated for debridement and removal of necrotic bone, followed by application of autologous platelet concentrate enriched with growth factors and primary suture of the wound. Patients underwent periodic clinical and radiological follow-up examinations. All patients showed clinical improvement and oral lesions resolved 2-4 weeks after treatment. After an average 14-month follow up period, patients remained asymptomatic. Although not conclusive, the combination of necrotic-bone curettage and platelet-rich-plasma to treat refractory osteonecrosis of the jaw yielded promising results. |
| Databáze: | OpenAIRE |
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