EHMTI-0184. Ictal adiponectin levels are modulated by pain severity and treatment response in episodic migraineurs
| Autor: | Gretchen E. Tietjen, Thomas N. Ward, BL Peterlin, Barbara A. Gower, Ann I. Scher, Nu Cindy Chai, Paul D. Dash, Linda W. White, Bizu Gelaye |
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| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Treatment response Adiponectin business.industry Clinical Neurology food and beverages General Medicine Bioinformatics Gastroenterology Anesthesiology and Pain Medicine Internal medicine Pain severity Meeting Abstract medicine Ictal Neurology (clinical) business After treatment |
| Zdroj: | The Journal of Headache and Pain |
| ISSN: | 1129-2369 |
| DOI: | 10.1186/1129-2377-15-s1-e25 |
| Popis: | Results A total of 34 participants (17 responders, 17 nonresponders) were included. In all participants, for every 1 point increase in the HMW:T-ADP ratio, pain severity increased by 4.11 (CI: 0.44, 7.77; p = 0.028). In responders (n = 17), crude T-ADP levels were reduced at 30 min (11.49 ± 3.7; p = 0.001), 60 min (11.54 ± 3.2; p = 0.001) and 120 min (11.39 ± 3.7; p = 0.001) after treatment as compared to onset (12.47 ± 3.6). In non-responders (n = 17), crude T-ADP levels were unchanged after treatment. After adjustments, T-ADP levels remained decreased 30120 min after treatment in responders; additionally, HMW-ADP, and the HMW:T-ADP ratio were decreased and LMW-ADP and the LMW:T-ADP ratio (coeff 0.04; CI: 0.01, 0.07; p = 0.043) were increased 120 min after treatment in responders. In non-responders, the adjusted LMW-ADP (coef -0.45; CI: -0.77, -0.14; p = 0.005) and the LMW:T-ADP ratio (coef -0.04; CI: -0.07, -0.01; p = 0.018) were decreased at 60 min as well as at 120 min after treatment. Unadjusted and adjusted LEP levels were not modulated by changes in pain severity or treatment response. |
| Databáze: | OpenAIRE |
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