Interferon-inducible Mx proteins in fish
| Autor: | Carol H. Kim, Ben Simon, Jo-Ann C. Leong, Marc C. Johnson, Grant Trobridge |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Signal peptide
Myxovirus Resistance Proteins Leucine zipper Immunology Molecular Sequence Data Biology Antiviral Agents GTP Phosphohydrolases Mice GTP-binding protein regulators Interferon GTP-Binding Proteins medicine Immunology and Allergy Animals Humans Amino Acid Sequence Peptide sequence Cellular localization Fishes RNA Proteins Molecular biology Rats Interferons Binding domain medicine.drug |
| Zdroj: | Immunological reviews. 166 |
| ISSN: | 0105-2896 |
| Popis: | Mx proteins are members of a family of interferon-inducible genes expressed when cells are treated with double-stranded RNA or virus infection. These proteins are important components of the antiviral response and form the first line of the body's defense against virus infections. The exact mechanism of action for these proteins has not been discovered, but mice missing the Mx genes are extremely sensitive to influenza virus infection. Mammals have between two and three Mx genes whose functions may vary with regard to the inhibition of a specific virus, cellular localization, and activity. The cDNA of three rainbow trout Mx proteins has been cloned and a comparison of their sequences with that of avian and mammalian species reveals striking conservation of domains. They all maintain the tripartite ATP/GTP binding domain and the dynamin family signature in the amino terminal half of the protein. In the carboxyl terminal half of the Mx proteins are the localization signals and the leucine zipper motifs which account for the trimerization of Mx in the cell. Like the rat and human Mx proteins, the different trout Mx proteins exhibit distinctly different immunohistochemical staining patterns in cells transfected with plasmids expressing RBTMx1, RBTMx2, or RBTMx3. To date, the antiviral function of the trout Mx proteins has not been satisfactorily established. |
| Databáze: | OpenAIRE |
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